Two New Oxysporone Derivatives from the Fermentation Broth of the Endophytic Plant Fungus Pestalotiopsis karstenii Isolated from Stems of Camellia sasanqua 英文参考文献.docVIP

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Two New Oxysporone Derivatives from the Fermentation Broth of the Endophytic Plant Fungus Pestalotiopsis karstenii Isolated from Stems of Camellia sasanqua 英文参考文献.doc

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Two New Oxysporone Derivatives from the Fermentation Broth of the Endophytic Plant Fungus Pestalotiopsis karstenii Isolated from Stems of Camellia sasanqua 英文参考文献

Molecules 2012, 17, 8554-8560; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Two New Oxysporone Derivatives from the Fermentation Broth of the Endophytic Plant Fungus Pestalotiopsis karstenii Isolated from Stems of Camellia sasanqua Du Qiang Luo 1,2,*, Lei Zhang 1,2, Bao Zhong Shi 2 and Xiao Mei Song 1 1 Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Baoding 071002, China 2 College of Life Science, Hebei University, Baoding 071002, China * Author to whom correspondence should be addressed; E-Mail: duqiangluo@163.com; Tel.: +86-0312-592-9898; Fax: +86-0312-595-9009. Received: 5 June 2012; in revised form: 30 June 2012 / Accepted: 5 July 2012 / Published: 17 July 2012 Abstract: Two new oxysporone derivatives, pestalrone A (1) and pestalrone B (2), along with two known structurally related compounds 3,4, were from the fermentation broth of the endophytic plant fungus Pestalotiopsis karstenii isolated from stems of Camellia sasanqua. Their structures and relative configurations were elucidated by extensive spectroscopic analysis and comparison of chemical shifts with related known compounds. Compound 2 exhibited significant activities agains HeLa, HepG2 and U-251 with IC50 values of 12.6, 31.7 and 5.4 μg/mL, respectively. Keywords: Pestalotiopsis karstenii; secondary metabolites; pestalrone A; pestalrone B 1. Introduction Pestalotiopsis species (family Amphisphaeriaceae) are widely distributed all over the World. Most of them are plant pathogens and many are saprobes in soil or in plant debris [1,2]. Previous investigations on some species of this genus have led to the isolation of numerous structurally diverse metabolites [3–16], including production of important compounds such as taxol [15,16]. During an ongoing search for new bioactive natural products from species of this genus, a strain of Pestalotiopsis karstenii isolated from stems