Two Novel Naphthalene Glucosides and an Anthraquinone Isolated from Rumex dentatus and Their Antiproliferation Activities in Four Cell Lines 英文参考文献.docVIP

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Two Novel Naphthalene Glucosides and an Anthraquinone Isolated from Rumex dentatus and Their Antiproliferation Activities in Four Cell Lines 英文参考文献.doc

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Two Novel Naphthalene Glucosides and an Anthraquinone Isolated from Rumex dentatus and Their Antiproliferation Activities in Four Cell Lines 英文参考文献

Molecules 2012, 17, 843-850; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Two Novel Naphthalene Glucosides and an Anthraquinone Isolated from Rumex dentatus and Their Antiproliferation Activities in Four Cell Lines Hui Zhang, Zengjun Guo *, Nan Wu, Wenming Xu, Ling Han, Nan Li and Yanxia Han Faculty of Pharmacy, School of Medicine, Xian Jiaotong University, No. 76 West Yanta Road, Xian 710061, China * Author to whom correspondence should be addressed; E-Mail: guozj@; Tel.: +86-29-8265-5133; Fax: +86-29-8265-5133. Received: 6 December 2011; in revised form: 6 January 2012 / Accepted: 9 January 2012 / Published: 17 January 2012 Abstract: An ethyl acetate extract of the roots of Rumex dentatus L. was investigated. Three compounds were identified by their spectroscopic data as chrysophanol (1), 6-methyl-7-acetyl-1, 8-dihydroxy-3-methoxy naphthalene-1-O-β-D(L)-glucoside (2) and 6-methyl-7-acetyl-1, 8-dihydroxy naphthalene-1-O-β-D(L)-glucoside (3) were found in the plant for the first time. Compounds 2 and 3 are novel compounds. Their antiproliferation activities were tested by the MTT assay in four cell lines (breast cancer MCF-7, gastric cancer 7901, melanoma A375 and oophoroma SKOV-3). Keywords: naphthalene; glucoside; anthraquinone; Rumex dentatus; antiproliferation 1. Introduction Rumex, the second genera among the Polygonaceae, comprises about 150 species widely distributed around the World. In China, it is represented by 26 species. Rumex dentatus is one of them, which could be found almost everywhere in China [1]. This traditional herb has been used as a medicine for many kinds of bacterial and fungal infection diseases, such as dysentery, enteritis, acariasis and eczema [2]. Since Rumex is in the same family with Rheum, their chemical compositions have some common features, such as the presence of chrysophanol, emodin, aloe-emodin and