Two New Withanolide Lactones from Flos Daturae 英文参考文献.docVIP

Molecules 2011, 16, 5833-5839; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Two New Withanolide Lactones from Flos Daturae Hai-Xue Kuang *, Bing-You Yang, Yong-Gang Xia and Qiu-Hong Wang Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China * Author to whom correspondence should be addressed; E-Mail: hxkuang@; Tel.: +86 45182193001; Fax: +86 45182110803. Received: 1 June 2011; in revised form: 29 June 2011 / Accepted: 5 July 2011 / Published: 11 July 2011 Abstract: Chemical investigation of the 50% ethanol eluate fraction from a macroporous resin of flowers of Datura metel L. collected in the Jiangsu Province of China resulted in the isolation of two new withanolides, baimantuoluoline G (1) and baimantuoluoside H (2). Their structures were elucidated as (12β,6β,22R)-1,10-seco-6,12,27-trihydroxy-26-oxo- witha-3,5,24-trienolide-1-oic acid-ε-lactone (1) and (5β,6α,12β,22R)-5,6,12,27-tetra- hydroxy-1,26-dioxo-witha-2,24-dienolide-27-O-β-glucopyranoside (2) on the basis of extensive spectroscopic analysis (1D, 2D-NMR and HRESIMS) and chemical studies. Keywords: Flos Daturae; Datura metel L.; withanolide lactones 1. Introduction Flos Daturae is the dry flower of Datura metel L. (Solanaceae), which widely distributed in China [1]. Flos Daturae, known as “baimantuoluo” or “yangjinhua” in China, has been used for centuries in Traditional Chinese Medicine for the treatment of asthma, convulsions, pain, and rheumatism [2]. Flos Daturae has been found to be rich in tropane alkaloids [2]. Besides, a number of withanolides have also been isolated from Flos Daturae [3-8]. Recently Flos Daturae has been used clinically for the treatment of psoriasis in China [9]. The effective part for psoriasis, namely the non-alkaloid water-soluble fraction of Flos Daturae, has been demonstrated to have anti