Utility of Sulphones in Heterocyclic Synthesis Synthesis of Some Pyridine, Chromene and Thiophene Derivatives 英文参考文献.docVIP

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Utility of Sulphones in Heterocyclic Synthesis Synthesis of Some Pyridine, Chromene and Thiophene Derivatives 英文参考文献.doc

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Utility of Sulphones in Heterocyclic Synthesis Synthesis of Some Pyridine, Chromene and Thiophene Derivatives 英文参考文献

Molecules 2000, 5, 701-709 molecules ISSN 1420-3049 Utility of Sulphones in Heterocyclic Synthesis: Synthesis of Some Pyridine, Chromene and Thiophene Derivatives A. A. Fadda1*, Hala M. Refat2 and M. E. A. Zaki3 1Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt E-mail: sinfac@mum.mans.eun.eg 2Department of Chemistry, Faculty of Education, Suez Canal University, Al-Arish, Egypt 3National Research Cente Dokki, Cairo, Egypt Fax: 002023370931, E-mail: mzaki@nrc.sci.eg * Author to whom correspondence should be addressed. Received:3 August 1999;revised form:13 October 1999/Accepted:13 October 1999/Published:5May 2000 Abstract: Phenylsulfonylacetonitrile (1) when reacted with a ,b-unsaturated nitriles (2a,b) and/or 2-hydroxynaphthaldehyde yields pyridine derivatives (3a,b) and / or the imino- chromene derivative (4) respectively. The behavior of (1) towards some a -halogenated compounds has been investigated. Keywords: Phenylsulfonylacetonitrile, pyridine derivatives, chromene derivatives, thio- phene derivatives. Introduction This work is the continuation of a program with the aim to develop new simple methods for the synthesis of functionally substituted heterocycles with anticipated biological activity. We have recently extended it to include the investigation of the pharmacological aspects of the newly synthesized he- terocycles based on the finding that some heterocycles can achieve activity in both the pharmacologi- cal and pesticidal areas, e.g. thiabenzdazole, the well known human and veterinary anthelmentic, is also used as a fungicide [1,2]. ? 2000 by MDPI (). Reproduction is permitted for noncommercial purposes. 702 Molecules 2000, 5 Results and Discussion Pyridines and chromene derivatives have recently received considerable attention due to their syn- thetic and pharmaceutical importance and different approaches for their synthesis have been developed [3,5a-c]. I