Utilization of a ts-sacB selection system for the generation of a Mycobacterium avium serovar-8 specific glycopeptidolipid allelic exchange mutant 英文参考文献.docVIP

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Utilization of a ts-sacB selection system for the generation of a Mycobacterium avium serovar-8 specific glycopeptidolipid allelic exchange mutant 英文参考文献.doc

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Utilization of a ts-sacB selection system for the generation of a Mycobacterium avium serovar-8 specific glycopeptidolipid allelic exchange mutant 英文参考文献

Annals of Clinical Microbiology and Antimicrobials BioMedCentral Research Open Access Utilization of a ts-sacB selection system for the generation of a Mycobacterium avium serovar-8 specific glycopeptidolipid allelic exchange mutant Vida R Irani1, Sun-Hwa Lee2, Torsten M Eckstein3, Julia M Inamine3, John T Belisle3 and Joel N Maslow*1,4 Address: 1School of Medicine, Division of Infectious Diseases, University of Pennsylvania, Philadelphia, PA 19104, USA, 2Harvard Medical School, New England Regional Primate Center, Southborough, MA 01772, USA, 3Mycobacterial Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins CO 80523, USA and 4Section of Infectious Diseases, VA Medical Center, Philadelphia PA 19104, USA Email: Vida R Irani - virani@; Sun-Hwa Lee - Sun-Hwa_Lee@; Torsten M Eckstein - torsten.eckstein@; Julia M Inamine - julia.inamine@; John T Belisle - john.belisle@; Joel N Maslow* - joel.maslow@ * Corresponding author Published: 30 September 2004 Received: 20 April 2004 Accepted: 30 September 2004 Annals of Clinical Microbiology and Antimicrobials 2004, 3:18 doi:10.1186/1476-0711-3-18 This article is available from: /content/3/1/18 ? 2004 Irani et al; licensee BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Mycobacterium avium are ubiquitous environmental organisms and a cause of disseminated infection in patients with end-stage AIDS. The glycopeptidolipids (GPL) of M. avium are proposed to participate in the pathogenesis of this organism, however, establishment of a clear role for GPL in disease production has been limited by the inability to genetically manipulate M. avium. Methods: To be able to study the role of the GPL in