Utilizing of Square Wave Voltammetry to Detect Flavonoids in the Presence of Human Urine 英文参考文献.docVIP

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Utilizing of Square Wave Voltammetry to Detect Flavonoids in the Presence of Human Urine 英文参考文献.doc

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Utilizing of Square Wave Voltammetry to Detect Flavonoids in the Presence of Human Urine 英文参考文献

Sensors 2007, 7, 2402-2418 sensors ISSN 1424-8220 ? 2007 by MDPI /sensors Full Research Paper Utilizing of Square Wave Voltammetry to Detect Flavonoids in the Presence of Human Urine Vojtech Adam 1,2, Radka Mikelova 3, Jaromir Hubalek 4, Pavel Hanustiak 5, Miroslava Beklova 5, Petr Hodek 6, Ales Horna 7, Libuse Trnkova 4, Marie Stiborova 6, Ladislav Zeman 2 and Rene Kizek 1,* 1 Department of Chemistry and Biochemistry, Mendel University of Agriculture and Forestry, Zemedelska 1, CZ-613 00 Brno, Czech Republic 2 Department of Animal Nutrition and Forage Production, Faculty of Agronomy, Mendel University of Agriculture and Forestry, Zemedelska 1, CZ-613 00 Brno, Czech Republic 3 Department of Chemistry, Faculty of Science, Masaryk University, Kotlarska 37, CZ-611 37 Brno, Czech Republic 4 Department of Microelectronics, Faculty of Electrical Engineering and Communication, Brno University of Technology, Udolni 53, CZ-602 00 Brno, Czech Republic 5 Department of Veterinary Ecology and Environmental Protection, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences, Palackeho 1-3, CZ-612 42 Brno, Czech Republic 6 Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, CZ-128 40 Prague, Czech Republic 7 Department of Food Engineering, Faculty of Technology, Tomas Bata University, CZ-762 72 Zlin, Czech Republic * Author to whom correspondence should be addressed. E-mail: kizek@sci.muni.cz Received: 10 September 2007 / Accepted: 17 October 2007 / Published: 19 October 2007 Abstract: About biological affecting of flavonoids on animal organisms is known less, thus we selected flavonoids, flavanones and flavones, and their glycosides, which were examined as potential inducers of cytochrome(s) P450 when administrated by gavages into experimental male rats. The study was focused on induction of CYP1A1, the major cytochrome P450 involved in carcinogen activation. The dat