Venous oxygen saturation as a physiologic transfusion trigger 英文参考文献.docVIP

Vallet et al. Critical Care 2010,14:213 /content/14/2/213 RE VIE W Venous oxygen saturation as a physiologic transfusion trigger Benoit Vallet*, Emmanuel Robin and Gilles Lebu? e This article is one of ten reviews selected from the Yearbook of Intensive Care and Emergency Medicine 2010 (Springer Verlag) and co-published as a series in Critical Care. Other articles in the series can be found online at http://ccforum/series/yearbook. Further information about the Yearbook of Intensive Care and Emergency Medicine is available from /series/2855. Introduction SvO )/SaO or even simpler: O ER ≈ 1 – SvO2. Assuming 2 2 2 Venous oxygen saturation is a clinical tool which inte- SaO = 1 [3], if SvO is 40%, then O ER is 60%. 2 2 2 grates the whole body oxygen uptake-to-delivery (VO - Because it integrates Hb, cardiac output, VO and SaO2, 2 2 DO ) relationship. In the clinical setting, in the absence the venous oxygen saturation therefore helps to assess 2 of pulmonary artery catheter (PAC)-derived mixed the VO -DO relationship and tolerance to anemia during 2 2 venous oxygen saturation (SvO ), the central venous blood loss. 2 oxygen saturation (ScvO ) is increasingly being used as a 2 reasonably accurate surrogate [1]. Central venous catheters (CVCs) are simpler to insert, and generally safer and Venous oxygen saturation as a physiologic transfusion trigger cheaper than PACs e CVC allows sampling of blood When DO decreases beyond a certain threshold, it 2 for measurement of ScvO or even continuous monitor- induces a decrease in VO is point is known as the 2 2 ing if an oximetry catheter is being use e normal critical DO (DO crit), below which there is a state of 2 2 range for SvO is 68 to 77% and ScvO2 is considered to be VO -DO dependency