Versatile and open software for comparing large genomes 英文参考文献.docVIP

Open Access So are 2004KurtzetVoal.lumeftw5, Issue 2, Article R12 Versatile and open software for comparing large genomes Stefan Kurtz*, Adam Phillippy?, Arthur L Delcher?, Michael Smoot??, Martin Shumway?, Corina Antonescu? and Steven L Salzberg? Addresses: *Center for Bioinformatics, University of Hamburg, Bundesstrasse 43, 20146 Hamburg, Germany. ?The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA. ?Current address: Department of Computer Science, University of Virginia, Charlottesville, VA 22904, USA. Correspondence: Steven L Salzberg. E-mail: salzberg@ Published: 30 January 2004 Genome Biology 2004, 5:R12 Received: 27 October 2003 Revised: 15 December 2003 Accepted: 17 December 2003 The electronic version of this article is the complete one and can be found online at /2004/5/2/R12 ? 2004 Kurtz et al.; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the articles original URL. VersatileTsbntaehrswaeetnesayednswbdteyfandsmratepviepselopenyrltishcriaeotdnfiiosoftwarersonstfrtsiMvbtoeuUrtmsMeiuotmforhnlteeioprccomparingfloeeMadgseUei.lnMyTohhmmeaeenMrsdlarge.tUloTeMswbceomogenomesrnmparisonseerlwesogsureradcpeahssicaofarpelelargevanive-aswoiilueukaryoticnarbgclteosaootlsfhtpwttrpaogenomesr:v/i/.dwTehwaiwlste.atratlinlgoarvaryingw.toisvego/twhsoaeyfrevolutionarytsdwteaovraeeln/omaplyeurzmsemtgdistances,oeencroo. nmtreiabluigastenmtdemon-oents.the cTheode Abstract The newest version of MUMmer easily handles comparisons of large eukaryotic genomes at varying evolutionary distances, as demonstrated by applications to multiple genomes. Two new graphical viewing tools provide alternative ways to analyze genome alignments. The new system is the first version of MUMmer to be released as open-source software. This allows other developers to contribute to the