Vasopressin and epinephrine in the treatment of cardiac arrest an experimental study 英文参考文献.docVIP

Available online /content/12/2/R40 Research Open Access Vol 12 No 2 Vasopressin and epinephrine in the treatment of cardiac arrest: an experimental study Konstantinos Stroumpoulis, Theodoros Xanthos, Georgios Rokas, Vassiliki Kitsou, Dimitrios Papadimitriou, Ioannis Serpetinis, Despina Perrea, Lila Papadimitriou and Evangelia Kouskouni University of Athens, Medical School, Department of Experimental Surgery and Surgical Research, Agiou Thoma Street, Athens, Greece Corresponding author: Theodoros Xanthos, theodorosxanthos@ Received: 22 Oct 2007 Revisions requested: 13 Dec 2007 Revisions received: 4 Jan 2008 Accepted: 14 Mar 2008 Published: 14 Mar 2008 Critical Care 2008, 12:R40 (doi:10.1186/cc6838) This article is online at: /content/12/2/R40 ? 2008 Stroumpoulis et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background Epinephrine remains the drug of choice for cardiopulmonary resuscitation. The aim of the present study is to assess whether the combination of vasopressin and epinephrine defibrillation was attempted after 10 minutes of ventricular fibrillation. (0.02 mg/kg) (Vaso-Epi group). Electrical epinephrine, given their different mechanisms of action, epinephrine alone in provides better results than Results Ten of 11 animals in the Vaso-Epi group restored spontaneous circulation in comparison to only 4 of 11 in the Epi group (p = 0.02). Aortic diastolic pressure, as well as, coronary perfusion pressure were significantly increased (p 0.05) during cardiopulmonary resuscitation in the Vaso-Epi group. cardiopulmonary resuscitation. Methods Ventricular fibrillation was induced in 22 Landrace/ Large-White piglets, which were left untreated f