Viral Determinants of FeLV Infection and Pathogenesis Lessons Learned from Analysis of a Natural Cohort 英文参考文献.docVIP

Viruses 2011, 3, 1681-1698; doi:10.3390/v3091681 OPEN ACCESS viruses ISSN 1999-4915 /journal/viruses Review Viral Determinants of FeLV Infection and Pathogenesis: Lessons Learned from Analysis of a Natural Cohort Lisa L. Bolin 1,2 and Laura S. Levy 1,2, * 1 Department of Microbiology and Immunology, School of Medicine, Tulane University, 1430 Tulane Avenue SL-38, New Orleans, LA 70112, USA; E-Mail: lbolin@ Tulane Cancer Center, School of Medicine, Tulane University, 1430 Tulane Avenue SL-38, New Orleans, LA 70112, USA 2 * Author to whom correspondence should be addressed; E-Mail: llevy@; Tel.: +1-504-988-3291; Fax: +1-504-988-2951. Received: 29 July 2011; in revised form: 31 August 2011 / Accepted: 1 September 2011 / Published: 9 September 2011 Abstract: Detailed analysis has been performed over many years of a geographic and temporal cohort of cats naturally infected with feline leukemia virus (FeLV). Molecular analysis of FeLV present in the diseased tissues and application of those viruses to experimental systems has revealed unique isolates with distinctive disease potential, previously uncharacterized virus-receptor interactions, information about the role of recombinant viruses in disease induction, and novel viral and cellular oncogenes implicated in pathogenesis, among other findings. The studies have contributed to an understanding of the selective forces that lead to predominance of distinctive FeLV isolates and disease outcomes in a natural population. Keywords: feline leukemia virus; lymphoma; pathogenesis; oncogenesis; long terminal repeat; surface glycoprotein 1. Introduction Feline leukemia virus (FeLV) is a horizontally-transmissible, naturally occurring retrovirus of the domestic cat, associated with proliferative, degenerative and malignant diseases of myeloid, erythroid, and lymphoid origin in the natural host. This complex disease spectrum is thought to