Virtual karyotyping with SNP microarrays reduces uncertainty in the diagnosis of renal epithelial tumors 英文参考文献.docVIP

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Virtual karyotyping with SNP microarrays reduces uncertainty in the diagnosis of renal epithelial tumors 英文参考文献.doc

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Virtual karyotyping with SNP microarrays reduces uncertainty in the diagnosis of renal epithelial tumors 英文参考文献

Diagnostic Pathology BioMedCentral Research Open Access Virtual karyotyping with SNP microarrays reduces uncertainty in the diagnosis of renal epithelial tumors Jill M Hagenkord1, Anil V Parwani1, Maureen A Lyons-Weiler2, Karla Alvarez3, Robert Amato3, Zoran Gatalica4, Jose M Gonzalez-Berjon5, Leif Peterson3, Rajiv Dhir1 and Federico A Monzon*3,5,6 Address: 1Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA, 2Clinical Genomics Facility, University of Pittsburgh, Pittsburgh, PA, USA, 3Department of Pathology, The Methodist Hospital Research Institute, Houston, TX, USA, 4Department of Pathology, Creighton University Medical Center, Omaha, NE, USA, 5Department of Pathology, The Methodist Hospital, Houston, TX, USA and 6Pathology, Weill Medical College of Cornell University, New York, NY, USA Email: Jill M Hagenkord - jillhagenkord@; Anil V Parwani - parwaniav@; Maureen A Lyons- Weiler - lyonsweilerma@; Karla Alvarez - kalvarez@; Robert Amato - Robert.Amato@; Zoran Gatalica - zgatalica@; Jose M Gonzalez-Berjon - jmgonzalezberjon@; Leif Peterson - lepeterson@; Rajiv Dhir - dhirr@; Federico A Monzon* - famonzon@ * Corresponding author Published: 6 November 2008 Received: 18 September 2008 Accepted: 6 November 2008 Diagnostic Pathology 2008, 3:44 doi:10.1186/1746-1596-3-44 This article is available from: /content/3/1/44 ? 2008 Hagenkord et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Renal epithelial tumors are morphologically, biologically, and clinically heterogeneous. Different morphologic subtypes require specific management due to markedly different prognosis and response to therapy. Each common subtype has characteristic chromosomal