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Antioxidant micronutrients in the critically ill a systematic review and meta-analysis.doc

Antioxidant micronutrients in the critically ill a systematic review and meta-analysis

Manzanaresetal.CriticalCare2012,16:R66 /content/16/2/R66 RESEARCH OpenAccess Antioxidantmicronutrientsinthecriticallyill:a systematicreviewandmeta-analysis WilliamManzanares1,RupinderDhaliwal2,XuranJiang2,LaurenMurch2andDarenKHeyland2,3* Abstract Introduction:Criticalillnessischaracterizedbyoxidativestress,whichisamajorpromoterofsystemic inflammationandorganfailureduetoexcessivefreeradicalproduction,depletionofantioxidantdefenses,orboth. Wehypothesizedthatexogenoussupplementationoftraceelementsandvitaminscouldrestoreantioxidantstatus, improvingclinicaloutcomes. Methods:Wesearchedcomputerized

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