原创力文档Assessing the metabolic effects of prednisolone in healthy volunteers using urine metabolic profiling.docVIP
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Assessing the metabolic effects of prednisolone in healthy volunteers using urine metabolic profiling
Ellero-Simatosetal.GenomeMedicine2012,4:94
/content/4/11/94
RESEARCH
OpenAccess
Assessingthemetaboliceffectsofprednisolone
inhealthyvolunteersusingurinemetabolic
profiling
SandrineEllero-Simatos1,2,3*,EwaSzymańska2,4,TonRullmann3,5,WimHADokter3,6,RaymondRamaker1,2,
RuudBerger2,7,ThijsMPvanIersel8,9,AgeKSmilde2,4,ThomasHankemeier1,2 andWynandAlkema3,10
Abstract
Background:Glucocorticoids,suchasprednisolone,arewidelyusedanti-inflammatorydrugs,buttherapyis
hamperedbyabroadrangeofmetabolicsideeffectsincludingskeletalmusclewastingandinsulinresistance.
Therefore,developmentofimprovedsynthetic
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