Endotoxin-induced myocardial dysfunction in senescent rats.docVIP

Available online /content/10/4/R124 Research Open Access Vol 10 No 4 Endotoxin-induced myocardial dysfunction in senescent rats Sandrine Rozenberg1,2, Sophie Besse3, Hélène Brisson1, Elsa Jozefowicz1, Abdelmejid Kandoussi4, Alexandre Mebazaa5, Bruno Riou6, Beno?t Vallet1,2 and Beno?t Tavernier1,2 1Université Lille 2, Laboratoire de pharmacologie, EA 1046, Centre hospitalier universitaire (CHU) de Lille, Lille, France 2Fédération danesthésie réanimation, CHU de Lille, Lille, France 3Laboratoire de recherche sur la croissance cellulaire, la réparation et la régénération tissulaires, UMR CNRS 7149, Université Paris 12 – Val de Marne, Créteil and Université René Descartes – Paris 5, Paris, France 4INSERM-Institut Pasteur, U545, 1 rue du Pr. Calmette, Lille, France 5Université Denis Diderot – Paris 7, Laboratoire danesthésiologie, EA 322, Département danesthésie-réanimation, CHU Lariboisière, Assistance Publique-H?pitaux de Paris (AP-HP), Paris, France 6Université Pierre et Marie Curie – Paris 6, Laboratoire danesthésiologie, EA 3975, Service daccueil des urgences, CHU Pitié-Salpêtrière, Assistance Publique-H?pitaux de Paris, Paris, France Corresponding author: Beno?t Tavernier, btavernier@chru-lille.fr Received: 12 Jun 2006 Revisions requested: 31 Jul 2006 Revisions received: 15 Aug 2006 Accepted: 30 Aug 2006 Published: 30 Aug 2006 Critical Care 2006, 10:R124 (doi:10.1186/cc5033) This article is online at: /content/10/4/R124 ? 2006 Rozenberg et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Aging is associated with a decline in cardiac contractility and altered immune function. The aim of this study was to determine whether aging alters endotoxin-induced myocardial dysfunction. control; P