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Evidence of functional selection pressure for alternative splicingevents that accelerate evolution of protein subsequences.doc

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Evidence of functional selection pressure for alternative splicingevents that accelerate evolution of protein subsequences

This information has not been peer-reviewed. Responsibility for the findings rests solely with the author(s). Deposited research article Evidence of functional selection pressure for alternative splicing events that accelerate evolution of protein subsequences Yi Xing and Christopher Lee Address: Molecular Biology Institute, Center for Genomics and Proteomics, Dept. of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095-1570, USA. Correspondence: Christopher Lee. E-mail: leec@ Posted: 11 April 2005 Received: 6 April 2005 Genome Biology 2005, 6:P8 The electronic version of this article is the complete one and can be found online at /2005/6/5/P8 This is the first version of this article to be made available publicly and no other version is available at present. ? 2005 BioMed Central Ltd .deposited research AS A SERVICE TO THE RESEARCH COMMUNITY, GENOME BIOLOGY PROVIDES A PREPRINT DEPOSITORY TO WHICH ANY ORIGINAL RESEARCH CAN BE SUBMITTED AND WHICH ALL INDIVIDUALS CAN ACCESS FREE OF CHARGE. ANY ARTICLE CAN BE SUBMITTED BY AUTHORS, WHO HAVE SOLE RESPONSIBILITY FOR THE ARTICLES CONTENT. THE ONLY SCREENING IS TO ENSURE RELEVANCE OF THE PREPRINT TO GENOME BIOLOGYS SCOPE AND TO AVOID ABUSIVE, LIBELLOUS OR INDECENT ARTICLES. ARTICLES IN THIS SECTION OF THE JOURNAL HAVE NOT BEEN PEER-REVIEWED. EACH PREPRINT HAS A PERMANENT URL, BY WHICH IT CAN BE CITED. RESEARCH SUBMITTED TO THE PREPRINT DEPOSITORY MAY BE SIMULTANEOUSLY OR SUBSEQUENTLY SUBMITTED TO GENOME BIOLOGY OR ANY OTHER PUBLICATION FOR PEER REVIEW; THE ONLY REQUIREMENT IS AN EXPLICIT CITATION OF, AND LINK TO, THE PREPRINT IN ANY VERSION OF THE ARTICLE THAT IS EVENTUALLY PUBLISHED. IF POSSIBLE, GENOME BIOLOGY WILL PROVIDE A RECIPROCAL LINK FROM THE PREPRINT TO THE PUBLISHED ARTICLE. Genome Biology 2005, 6:P8 Evidence of Functional Selection Pressure for Alternative Splicing Events that Accelerate Evolution of Protein Subsequences Yi X