Exercise and cognitive function a hypothesis for the association of type II diabetes mellitus and Alzheimers disease from an evolutionary perspective.docVIP

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Exercise and cognitive function a hypothesis for the association of type II diabetes mellitus and Alzheimers disease from an evolutionary perspective.doc

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Exercise and cognitive function a hypothesis for the association of type II diabetes mellitus and Alzheimers disease from an evolutionary perspective

Diabetology Metabolic Syndrome BioMedCentral Review Open Access Exercise and cognitive function: a hypothesis for the association of type II diabetes mellitus and Alzheimers disease from an evolutionary perspective Gilberto NO Brito1,2 Address: 1Setor de Neurociências, Departamento de Pediatria, Instituto Fernandes Figueira, FIOCRUZ, Rio de Janeiro, RJ, Brasil and 2Departamento de Psiquiatria e Saúde Mental, Instituto de Saúde da Comunidade, Universidade Federal Fluminense, Niterói, RJ, Brasil Email: Gilberto NO Brito - ccsgnob@vm.uff.br Published: 18 September 2009 Received: 4 May 2009 Accepted: 18 September 2009 Diabetology Metabolic Syndrome 2009, 1:7 doi:10.1186/1758-5996-1-7 This article is available from: /content/1/1/7 ? 2009 Brito; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract The association of type II diabetes mellitus (DM2) with Alzheimers disease (AD) has received considerable attention in recent years. In the present paper, a hypothesis for this association from an evolutionary perspective, with emphasis on the close interplay between exercise and cognitive function, will be advanced in order to provide a biological rationale for the notion that the fundamental metabolic features of DM2 act in the brain over a protracted time span to induce the neuropathological characteristics of Alzheimers disease thereby producing cognitive impairment. It is hoped that this hypothesis puts the association of DM2 and AD on firm conceptual grounds from a biological perspective and offers directions for further research. The great evolutionary biologist Theodosius Dobzhansky once said: Nothing in biology makes sense except in the light of evolution. Along this line, I will