Extensive genomic diversity and selective conservation of virulence-determinants in enterohemorrhagic Escherichia coli strains of O157 and non-O157 serotypes.docVIP

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Extensive genomic diversity and selective conservation of virulence-determinants in enterohemorrhagic Escherichia coli strains of O157 and non-O157 serotypes.doc

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Extensive genomic diversity and selective conservation of virulence-determinants in enterohemorrhagic Escherichia coli strains of O157 and non-O157 serotypes

Open Access Re rch 2007OguraetVoal.lumesea8, Issue 7, Article R138 Extensive genomic diversity and selective conservation of virulence-determinants in enterohemorrhagic Escherichia coli strains of O157 and non-O157 serotypes Yoshitoshi Ogura*?, Tadasuke Ooka?, Asadulghani?, Jun Terajima?, Jean- Philippe Nougayrède§, Ken Kurokawa?, Kousuke Tashiro￥, Toru Tobe#, Keisuke Nakayama?, Satoru Kuhara￥, Eric Oswald§, Haruo Watanabe? and Tetsuya Hayashi*? Addresses: *Division of Bioenvironmental Science, Frontier Science Research Center, University of Miyazaki,5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan. ?Division of Microbiology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki,5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan. ?Department of Bacteriology, National Institute for Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo, 162-8640, Japan. §UMR1225, INRA-ENVT, 23 chemin des Capelles, 31076 Toulouse, France. ?Laboratory of Comparative Genomics, Graduate School of Information Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara, 630-0192, Japan. ￥Laboratory of Molecular Gene Technics, Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakosaki, Fukuoka, 812-8581, Japan. #Division of Applied Bacteriology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. Correspondence: Tetsuya Hayashi. Email: thayash@med.miyazaki-u.ac.jp Published: 10 July 2007 Received: 7 March 2007 Revised: 6 June 2007 Accepted: 10 July 2007 Genome Biology 2007, 8:R138 (doi:10.1186/gb-2007-8-7-r138) The electronic version of this article is the complete one and can be found online at /2007/8/7/R138 ? 2007 Ogura et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any