破骨细胞分化成熟因子与其信号转导通路_黄晓斌.pdf

2007 11 13 11 Chin J Osteoporos, November 2007,Vol 13, No1 11 803 ## 黄晓斌 孙元明 李雨民 杨福军 : , , , : RANKLTNF AIL 1 IL 61, 25 (OH) D PTHM CSF , RANKL M CSF 2 3 ; , : OPGIL 4IL 10TGF B OPGPRANKPRANKL , OPGPRANKPRANKL , MAPKNF kappaBCNPNFAT , , , : ; ; The cytokines of osteoclast and their path of signal transduction H UANG Xiaobin, SUN Yuanming, LI Yumin, et al. Department of Biomedicine, Institute of Radiation Medicine, AMS PUM , Tianj in 300192, China Abstract: It is a complicated process that osteoclast differentiates from progenitor to mature osteoclast which have the function of bone resorption. There are series of cytokines and systemic hormones involved in this phase. Some cytokines promote osteoclast development, such as RANKL,TNF A, IL 1, IL 6, 125 (OH) D ,PTH, M CSF, and 2 3 the list will go on, in which RANKL and M CSF are essential. Other cytokines inhibit osteoclast growth, such as OPG, IL 4, IL 10, estrogen, calcitonin,TGFB, and so on. The OPGPRANKPRANKL system is vital in the period. Most of cytokines play role through OPGPRANKPRANKL system directly or indirectly. The interaction between osteoclast and osteoblast or stromal cell is also important. There are several signal pathways such as MAPK, NF kappaB and CNPNFAT, involved in osteoclast differentiation. Understanding the cytokines of osteoclast and path of signal transduction respectively make it possible for us to comprehend the development and the treatment of the bone metabolic diseases. Key words: Osteoelast; Cytokine; Signal transduction , , , 20~ 100 Lm, 2~ 50 , , , ( osteoclast, OC) , 1 , , 111 (tumor necrosis factors, TRAP TNFs) , ,