乳腺癌转移相关基因的研究进展.pdfVIP

中国肿瘤生物治疗杂志 http://www. biother. org Chin J Cancer Biother , Apr. 2010 , VoL 17 , No. 2 .227. DOI: 10. 3872/j. ÏS8n. 1创)7-38SX. 2010. 02. 021 ·综述· 乳腺癌转移相关基因的研究进展 徐安1 综述:李 楠2 审阅(1.第二军医大学研究生院，上海 2∞433; 2. 第二军医大学基础医学部免疫学研究 所，上海 2∞433) [摘 要] 乳腺癌的转移是一个较为复杂、由多采间参与及多步骤完成的过程，转移相关基因对转移的调控是肿瘤发生转移 的分子基础。所谓转移相关基因是一类功能上能够促进或阻断肿瘤转移潜能而不影响肿瘤细胞生长增殖的基园，真总体可 分为两大类:转移促进基因和转移抑制l 基因，它们涉及精采肉、抑癌基肉、信号转导某网以及靠自附分子基因、细胞因子基因、基 质金属蛋白酶基因等。乳腺癌转移柑关呆间的作用机制放下游信号转导途径的阐明，将为转移件乳腺癌的分子诊断和个体 化治疗奠定基础。 [关键词] 乳腺肿瘤;转移;癌基因:抑癌基因:信号转导基因 [文献标志码] A [文章编号] 1∞7-385X( 2010 )02 -0227 -05 Advances of beast cancer metastasis related genes 1 2 XU An , LI Nan (1. Postgraduate Sch∞1 ， Second MilitaIγMedical University , Shanghai 200433 , China; 2. Institute of lmmunology , College of Basic MedicaI Sciences , Second Military Medical University , Shanghai 2∞433 ， China) [ Abstract] Breast cancer metastasis is a complicated process driven by multiple genes and follows multiple steps. 币le regulation of metastasis-associated genes is the molecular basis for metastasis. Metastasis-associated genes can promote or suppress the metastasis potential of tumor cells without affecting their growth and proliferation. Generally , metastasis-as回­ ciated genes fall into two categories: metastasis-promoter genes and metastasis-suppressor genes , including oncogenes , tumor suppressor genes , signaling molecule genes , adhesion molecule genes , cytokine genes , matrix metalloproteinase genes , etc. The elucidation of the underlying mechanisms of breast cancer metastasis-associated genes and the related downstream si伊aling pathways can facilitate the molecular dia伊osis and individualized therapy of patients with metastasic breast cancers. [ Key words] breast neoplasms; metastasis; oncogene; tumor suppressor gene; sigr时 trans