who2004版胸腺瘤的分类.pptVIP

  1. 1、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。。
  2. 2、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载
  3. 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
  4. 4、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
  5. 5、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们
  6. 6、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
  7. 7、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
who2004版胸腺瘤的分类

Type B3 A tumor comprised predominantly of epithelial cells with a round or polygonal shape and exhibiting mild atypia admixed with a minor component of lymphocytes; foci of squamous metaplasia and perivascular spaces are common Synonyms: Well-differentiated thymic carcinoma; epithelial thymoma; squamoid thymoma. Type B3 thymoma with invasion of pleura and pericardium. Macroscopy of B3 thymoma(left) and remnant thymus(right). Type B3 thymoma. A. Lobular growth pattern and infiltration into mediastinal fat (Masaoka stage Ⅱ). B. Clear cell areas (top and right) adjacent to an area with a common histology (darker region in lower left part of image). C. Ground glass appearance of tumor cells. Low number of intraepithelial lymphocytes. D. Large cell variant with B2-like large nuclei and prominent nucleoli: by its atypia the case appears “borderline” to squamous cell carcinoma of the thymus. Type B3 thymoma. A. Large cell variant: large nuclei and conspicuous nucleoli and paucity of intraepithelial lymphocytes. B. Typical perivascular spaces with tumor palisading. C. Large cell variant, lobular growth pattern; few intraepithelial lymphocytes. D. High power of figC. E. Hassall’s corpuscle in a B3 thymoma(rare). F. Abortive formation of Hassall’s corpuscles and vague spindling of tumor cells. 胸腺瘤和其上皮的免疫染色特点 胸腺瘤通常由两部分组成:上皮性和背景的未成熟小T淋巴细胞。 上皮性:CK19,CK7,CK14,CK5/6,P63; 但CK20-,CD5-,CD70-,CD117-。CK19阳性为网状分布。 T细胞:未成熟T: CD3,CD1a,TDT,CD99,Ki67有时高比例,可有少许B细胞。 胸腺癌时,上皮CD5,CD70,CD117,但背景的未成熟小T淋巴细胞多无,而伴成熟的T和B细胞。 Immunochemistry   Neoplastic epithelial cells   CK19 CK5/6 CK7 CK14 CK20 EMA AE1/3 CD57 CD5 CD20 CD70 Type A + - -   - focal   focal - focal   Type AB + - - +   +   weak - focal   Type B1 +   +   -       - - - Type B2 + + +   - - + + - - - Type B3 + + +   - + + + -* - -   Immature T cells Mature T cells       CD1a CD4 CD8 CD5 CD99 TdT CD3 CD5 CD1a CD99 TdT p53Ki67 Type A +         + + + - - - low or - Type AB +         + + + - - - low or - Type B1 + + + + + + + + - - - low

文档评论(0)

sandaolingcrh + 关注
实名认证
文档贡献者

该用户很懒,什么也没介绍

1亿VIP精品文档

相关文档