双语第十二章t淋巴细胞介导的细胞免疫应答双语.pptVIP

第十二章 T淋巴细胞介导的细 胞免疫应答 第一节 T细胞对抗原的识别 Antigens presentation Endogenous antigen, processed in the cytosolic pathway, presented with classⅠMHC protein to the CD8+T cell. Exogenous antigen, processed in the endocytic pathway, presented with classⅡMHC protein to the CD4+T cell. Interaction between APC and T cells Non-specific combination Specific combination Non-specific combination between APC and T cells Adhesion molecules （LFA-1、CD2） on T cells surface bind with corresponding ligands （ICAM-1、LFA-3）on APC, enhance the ability of T cells To recognize and bind to Ag. Reversible and temporal Specific combination between APC and T cells TCR recognize Ag-MHC complex (pMHC) specificly CD3 transmit the specific Ag signal CD4 and CD8 are co-receptors, which bind with MHC-Ⅱ and MHC-Ⅰ respectively and enhance the affinity of TCR and pMHC. Molecules involved in T cells activation First signal (Antigen signal): recognition of peptide-MHC complexes by the TCR CD3:transmit antigen stimulus signal CD4/CD8 classⅡ/ⅠMHC Second signal (Costimulatory signal) CD28 B7.1/B7.2 Cytokines promote T cells activation thoroughly (IL-1、IL-2、IL-12) Target genes involved in T cells activation signals Cytokine genes Cytokine receptor genes proto-oncogenes Adhesion molecule genes MHC Functions of Th1 cells The principal function of CD4+TH1 cells is in phagocyte-mediated defense against infections, especially with intracellula microbes, Functions of Th1 cells To macrophages: Activate macrophage through IFN-γ and CD40 Induce generation of macrophage through IL-3 and GM-CSF recruit macrophage through TNF-α、LTα和MCP-1 To lymphocytes: IL-2 promote activation and proliferation of Th1、Th2、CTL和NK IFN-γpromote B cell to generate Abs which have opsonization activity and enhance phagocytosis of macrophage To neutrophils: Activate neutrophils through lymphotoxins and TNF-α，promote it to kill pathogens Functions of CD8+CTLs The principal function of CD8+CTLs is in killing the