2010 (生命科学) HIV-1 Tat 蛋白神经毒作用的研究进展.pdf

22 1 Vol. 22, No. 1 2010 1 Chinese Bulletin of Life Sciences Jan., 2010 1004-0374(2010)01-0084-05 HIV-1 Tat (1 200433 2 200433) HIV-1 HIV-1 Tat Tat Tat NMDAR mGluR1 Ta t HIV-1 Tat Q291; R742 A Progress in study on neurotoxicity of HIV-1 Tat 1 2 TENG Jing-fei , GAO Xiao-fei * (1 Eight-year-system Clinical Medicine, Second Military Medical University, Shanghai 200433, China; 2 Department of Neurobiology, Second Military Medical University, Shanghai 200433, China) Abstract: Infection with HIV-1 is always associated with dysfunctions of central nervous system(CNS), the patients are characterized by motor dysfunctions, impaired cognitions and behaviors. Relative researches indi- cated that, various HIV-1 proteins are responsible for the pathogenesis, among which, Tat is of vital importance. Peripheral Tat, which can cross the blood-brain barrier and infiltrate the brain tissues, as well as that secreted or released from HIV-1-infected cells, can interact with NMDAR, mGluR1, dopamine transporter, etc. and thus cause damages to central nervous system (CNS). The neurotoxicity effects of HIV-1 Tat were reviewed here. Key words: HIV-1 Tat; blood-brain barrier; neurotoxicity HIV-1(human immunodeficiency virus 1)Tat HIV-1 Gp120Gp41 VprTatRevVpuNef Tat Tat 1Tat Tat HIV-1 Tat HIV-1 HIV-1 Tat Tat HIVE HAD