Graves眼病患者生长抑素受体闪烁显像的应用价值论文.docVIP

　　Graves眼病患者生长抑素受体闪烁显像的应用价值论文 赵荣 汪静 邓敬兰 梁晓燕 曾瑾 王江 【摘要】 目的：探讨99mTc-OCT生长抑素受体显像在活动期Graves眼病（GO）免疫治疗中的价值。方法：采用直接法标记制备99mTc-OCT，纸层析法测定标记率。GO患者15例，健康志愿者4例为正常对照组。注射99mTc-OCT 740MBq，4h后进行头部SPECT＋CT断层和左、右侧位平面显像，次日所有患者给予强的松(30mg/d，分3次服用，疗程为1mo)治疗后再次行99m Tc-OCT显像。测定2次显像眼眶（O）与枕部（OC）的感兴趣区（ROI）放射性计数及计算双侧眼眶（O）/枕叶（OC）放射性比值。计算GO患者治疗前、后的眼病指数（OI）,进行其临床活动度的评价。结果：活动期GO患者12例治疗前O/OC比值为(1.64±0.13)，显著高于正常对照（1.16±0.04）及治疗后(1.21±0.09)(P 0.05)；其治疗后O/OC比值及两者与对照组比较无显著性差别 (P＞0.05)。非活动期GO患者3例治疗前、后O/OC比值与对照组比较差别无显著性(P＞0.05)。结论：活动期GO患者眼眶明显摄取99mTc-OCT.freel Tc-OCT显像可作为GO患者选择激素治疗及评价疗效的客观而可靠的指标。 【关键词】 Graves眼病 生长抑素受体 单光子发射型计算机断层显像（SPECT） 99m锝 奥曲肽 Applied value of somatostatin receptor scintigraphy in patients opathy AbstractAIM: To investigate the evaluation of orbital somatostatin receptor scintigraphy Tc-OCT in patients opathys response to corticosteroid therapy. METHODS: OCT, a somatostatin analog, Tc by a direct method. The pounds labeling efficiency ed by paper chromatography. There opathy (GO) and 4 volunteers (control group, CG) ission puted tomography (SPECT), puted tomography (CT) and left/right lateral position planar imaging of the head Tc-OCT, corticosteroid therapy (methylprednisolone,10mg qo t i d. for 1 month) ed again after 1 month. Radioligand uptake easured using the region of interests (ROI) method and the O-to-OC ratio ined before and after corticosteroid treatment. Clinical activity of GO ent by calculating the ophthalmopathy index (OI). RESULTS: A significant change of O/OC ratio ent in 12 patients ent GO (1.16±0.04 vs 1.21±0.09, P 0.05) nor of O/OC ratio ent and post-treatment, and in those CG (P 0.05). CONCLUSION: In patient arkedly increased orbital uptake of 99mTc-OCT. The study demonstrated that 99mTc-OCT scintigraphy can predict the clinical response to corticosteroid therapy in patient ay be considered an objective and safety approach to select the patient for the proper treatment. · KEYo-99mTc发生器（凝胶型，Na99TcmO4放化纯＞98%）由四川成都中核高通同位素股份有限公司提供。99mTc-OCT制备采用直接标记法（具体方法及质量控制见