血红蛋白和免疫球蛋白_培训课件.pptVIP

As a result of this change, deoxyhemoglobin S has a hydrophobic patch on its surface, which causes the molecules to aggregate into strands that align into insoluble fibers. Sickle Cell Advantage Individuals heterozygous for sickle-cell hemoglobin have a higher resistance to malaria (疟疾) than those who do not carry the sickle-cell mutation. The malarial parasite spends a portion of its life cycle in human red cells, and the increased fragility of the sickled cells, even in heterozygous individuals, tends to interrupt this cycle. Heterozygous (杂合的) individuals have a higher survival rate-and