自身免疫与炎症性疾病的实验室检查.pdf

主堡塞旦』!登堕盎塑查!!!!生i旦笙!Q鲞箜!塑竺皇虫!垒￡出璺!垫里塑垫坚!堕翌垫!!!∑!!：!Q!塑!：! ·653· ·专家论坛· 自身免疫与炎症性疾病的实验室检查 张秋业柏翠 【摘要】 自身免疫性疾病是以识别自身／非己的适应性免疫耐受机制破坏导致的自身组织炎性损害，以 体内出现自身抗体和自身反应性T淋巴细胞为特征；自身炎症性疾病是一组遗传性复发性非侵袭性炎症性疾 病，以发热、皮疹、关节痛、关节炎、眼部病变和急性期蛋白增高为突出特征，可影响多器官系统。上述疾病起病 形式和临床表现多样，各种疾病间症状和体征相似并有重叠，也常易与其他系统性疾病相混淆，临床上极易发 生误诊或漏诊。正确认识和掌握儿童自身免疫性和自身炎症性疾病的实验室检查变化特点及其临床意义至关 重要，对上述疾病的临床诊断、鉴别诊断、病情评估及指导治疗有重要价值。 【关键词】 自身免疫性疾病；自身炎症性疾病；实验室检查 examinationofautoimmuneand diseases autoinflammatoryZhang Cui．Departmentof Laboratory Qiuye，Bai Province，China Pediatrics，theAffiliatedHospitalofQingdaoUniversity，Qingdao266003，Shandong author：ZhangQiuye，Email：qyzh9816@163．corn Corresponding diseaseisallOWN caused the organizationinflammatorylesions，mainlybydestroying 【Abstract】Autoimmune is the immunetolerancemechanismof character appearing adaptive differentiating。’self”and”non—self”．whose autoantibodiesandself—reactiveTcellsinthe diseaseiSa of and body．Autoinflammatorygroupgenetic．recurrent noninvasive characteristicsare inflammatorydisease，whose fever，rash，jointpain，arthritis，ophthalmicpathological and ofacute itcanaffect diseasesaredifferentinthe changesincreasingphaseproteins，and manyorgansystems．These modeofonsetandclinical alsocanhavesimilarand and oftencon— manifestations，but ovedappedsymptomssigns，and fusedwithother ormissed occur．Tounderstandcoto diseases．Therefore，cl