Chapter 4Distance–Based Methods of Phylogenetics.pptVIP

Chapter 4Distance–Based Methods of Phylogenetics 暨南大學資訊工程學系 黃光璿 (HUANG, Guan-Shieng) 2004/03/29 Motivation Evolution events on genomes: substitutions insertions deletions rearrangements We focus on cluster analysis in this chapter. 4.1 History of Molecular Phylogenetics taxonomists (分類學家)： naming (命名) grouping (分類) traditional approach based on anatomic difference (解剖) Linnaeu’s system 界 門 綱 目 科 屬 種 Darwing (達爾文) Nuttall (1902~1904) humans apes 最晚分化 (從免疫系統的角度) 1950s protein electrophoresis (size, charge) 1960s protein sequencing 1970s genomic information 先有 restriction enzyme 後有 DNA sequ