UC001kfoinhumanbreastcancer选编.PDFVIP

临床与病理杂志 2015, 35(11) 1992 J Clin Path ol R e s doi: 10.3978/j.issn.2095-6959.2015.11.027 View this article at: /10.3978/j.issn.2095-6959.2015.11.027 长链非编码RNA UC001kfo在乳腺癌组织中的表达及临床意义 黄秋霞，陈罡，韦康来，冯振博，陈皓 (广西医科大学第一附属医院病理科，广西 南宁 535021) [摘　要] 目的：检测长链非编码RNA UC001kfo在乳腺癌及癌旁组织中的表达水平，分析其与乳腺癌临床病 理特征的相关性。 方法：收集石蜡包埋的乳腺浸润性导管癌47 例及癌旁组织 16例，用实时荧光定 量PCR技术检测lncRNA UC001kfo 的表达水平，并用统计学方法分析其与临床病理特征的相关性。 结果：UC001kfo在乳腺癌组织中表达水平下调 (P 0.001) ；UC001kfo低表达与高临床分期呈负相关 r − P ( = 0.319 ， =0.029) 。结论：UC001kfo 可能在乳腺癌发生中起抑癌作用，可能成为乳腺癌诊断的 分子标记物及治疗的靶基因。 [关键词] 乳腺癌；UC001kfo ；肿瘤发生 The expression and significance of long non-coding RNA UC001kfo in human breast cancer HUANG Qiuxia, CHEN Gang, WEI Kanglai, FENG Zhenbo, CHEN Hao (Department of Pathology, the First Affiliated Hospital of Guangxi Medical University, Nanning Guangxi 530021, China) Abstract Objective: The present study is aim to detect the expression of UC001kfo in breast cancer tissues and normal tissues, then clarify the association between the expression of UC001kfo and the clinicopathological parameters of breast cancer patients. Methods: Forty-seven cases of invasive ductal carcinoma tissues and sixteen cases of adjacent no-tumor tissues which were fomalin-fixed, paraffin embedded (FFPE) were collected. The expressions of UC001kfo in these tissues were detected by using quantitative real-time polymerase chain reaction (qRT-PCR). Simultaneously, the correlation between the expression of t