老年周围动脉闭塞性疾病内皮与非内皮依赖性舒张功能的无创.PDFVIP

230 2003 8 5 4 Chin J Ger iatr Cardiovasc Cerebrovasc Dis Aug 2003 Vol 5 No 4 1 1 2 1 曹剑 , 李小鹰 , 赵沙沙 , 刘涛 ( 1. , 100853; 2. , 100857) : 目的 探讨老年周围动脉闭塞性疾病( peripheral arterial occlu sive disease, PAOD) 内皮依赖性舒张功能, 即 流 介导的 管扩张功能( lowmediated dilation, FMD) 和硝酸甘油介导的非内皮依赖性舒张功能( nitroglycerinmediated di lation, NMD) 状况及其相关因素方法 采用超声多普勒检测 33 例已确诊为 PAOD 的老年患者肱动脉 FMD 及 NMD, 并分别与40 例健康老年人及30 例具有心 管危险因素的老年非PAOD 患者进行对照研究结果 老年 PAOD 患者FMD 及NMD 均显著低于对照组; 肱动脉基础内径收缩压低密度脂蛋白胆固醇与 FMD 呈负相关; FMD 与NMD 呈正相关, 肱动脉基础内径与NMD 呈负相关结论 老年PAOD 患者FMD 及NMD 均受损; 肱动脉基础内 径收缩压低密度脂蛋白胆固醇可能是FMD 独立的预测因子; 而FMD 及肱动脉基础内径与NMD 密切相关 : 内皮; 动脉硬化, 闭塞性; 管舒张 : R543. 5 : A : 200 3) Noninvasive investigation on vasodilation in peripheral arterial occlusive disease of the elderly CAO Jian, LI Xiaoying, ZHAO Shasha, et al ( Chinese PLA General H osp ital , Beji ing 100853, China) Abstract: Objective To evaluate the endotheliumdependent( i. e. lowmediated dilation, FMD) and endothe liumindependent vasodilation( i. e. nitroglycerinmediated dilation, NMD) in peripheral arterial occlusive dis ease ( PAOD) o the elderly and to investigate the actors associated with FMD and NMD respectively. Methods Both FMD and NMD o the brachial artery in 33 old PAOD patients were examined by the color Doppler ul trasonograph and compared with 40 old healthy controls and 30 old nonPAOD patients with cardiovascular risk actors respect ively. Results Both FMD and NMD o the brachial artery in 33 old PAOD patients w