ANTIHYPERTENSIVES,DIURETICS,ANTICOAGULANTS分析.pptVIP

Fibrates Tricor (fenofibrate) Lopid (gemfibrozil) These drugs increase oxidation of fatty acids in liver and muscle tissue thus decreasing hepatic production of TG, VLDL and increase HDL. Most effective drugs for reducing TG. Fibrates cont. Can cause hepatotoxicity Main side effects include: diarrhea, GI discomfort, cause gallstones, interact with Coumadin Niacin (nicotinic acid) Decreases both cholesterol and triglycerides Bottom line—decreases hepatic synthesis of TG and secretion of VLDL (which leads to decreased production of LDL) Need high doses for efficacy Niacin Side effects include: