中药制药分离技术课程设计-口服液第一组.docVIP

《中药制药分离工程课程设计》 设计成绩： 批 阅 人： 批阅日期： 设计题目：芍甘口服液提取、精制工艺设计 设 计 者： 宋丹娟 班 级： 12中药制药 学 号： 046212108 指导教师： 郑云枫 设计日期： 2015年6月18日 南京中医药大学药学院 目录 设计任务书·············································4 概述····················································5 1.1芍甘汤·············································5 1.2芍药···············································5 1.3甘草···············································5 1.4配伍···············································5 常用精制技术简介········································6 2.1醇沉法·············································6 2.2膜分离法···········································6 2.2.1微滤··········································6 2.2.2超滤··········································6 2.3高速离心法·········································6 2.4澄清剂吸附法·······································6 2.5大孔树脂法·········································7 课程实验···············································8 3.1处方···············································8 3.2制法···············································8 3.3数据···············································8 3.3.1固含物········································8 3.3.2高效液相······································9 3.4口服液第二组数据··································10 3.4.1固含物·······································10 3.4.2高效液相·····································10 工艺流程及分析·········································12 5.总结················································14 参考文献·················································14 设计任务书 1.设计题目 芍甘汤提取、精制工艺设计 2.设计条件 芍甘口服液提取物的工艺设计 3.设计内容与要求 （1）确定提取工艺及参数； （2）确定精制分离工艺及参数； （3）提取物得率、成分含量以及相对密度； （5）编写设计说明书； 4.设计成果 （1）设计说明书一份 包括概述（简要说明所设计的复方中药效物质成分类型、性质及药理作用等）；常用精制分离技术简述（主要为醇沉、微滤）课程实验（不同精制方法的效果及比较）；工艺线路的设计（从最终制剂的剂型、工艺合理性以及生产成本等方面考虑）。 （2）芍甘汤提取精制工艺流程图； 5.设计时间 设计时间为2周，从2015年6月8日至2015年6月19日。 1.概述 1.1芍甘汤 芍甘口服液设计来源于芍甘汤，芍甘汤全称芍药甘草汤，来源于《伤寒论》。用法：12g芍药和12g甘草加水煎煮两次，合并煎液，分两次服用，早晚各一次。功用：调和肝脾，缓急止痛，主治津液受损，阴血不足，筋脉失濡所致诸证，如伤寒伤阴、筋脉失濡、腿脚挛急等。 方中芍药酸寒，养血敛阴，柔肝止痛；甘草甘温，健脾益气，缓急止痛。二药