EB病毒DNA与鼻咽癌值奈疗预后之相关联性.ppt

EB病毒 DNA与鼻咽癌治疗预后之相关联性The relationship between EBV DNA and prognosis in nasopharyngeal carcinoma ;Outline;The nasopharynx (nasal part of the pharynx) is the uppermost part of the pharynx It extends from the base of the skull to the upper surface of the soft palate ;Fossa of Rosenmuller;Examination of Nasopharynx;;Nasopharyngoscope;Fossa of Rosenmuller;Nasopharyngeal Carcinoma (NPC) ;Etiology --- Cause ?? Not clear EB virus - related to undifferentiated type Gene - (HLA-A2, Aw19, BSin 2, B17, BW16) Diet (salted vegetables, fish and meat - dimethylnitrosamines) Environment smoking, nickel exposure, formaldehyde(甲醛);NPC;Symptoms and Signs;Diagnosis and Treatment ;Related Articles of EBV DNA and NPC prognosis ;EBV DNA level and NPC recurrence;EBV DNA level and NPC recurrence;This study provide convincing evidence for the use of plasma EBV DNA measurements for the early diagnosis and staging of NPC a well as for monitoring recurrence and metastasis of this tumor Shao JY. et al. Cancer. 2004 The usefulness of EBV DNA as a useful tool in monitoring NPC by its ability to detect early recurrence and excellent correlation with treatment response Chan SL et al. BMC Cancer. 2006 The plasma EBV DNA assay correctly predicted all NPC recurrences, and PET had high capacity to localize potential lesion sites Wang WY et al. Cancer. 2011 ;The risks of loco-regional failure were not significantly different between patients with high and those with low EBV DNA levels Leung SF. et al. Cancer. 2003 Plasma EBV DNA load measurement appears to be useful in a low tumor risk area(western Europe). However, development of local recurrences may not always coincide with raised level of EBV DNA Kalpoe JS. et al. J Clin Pathol. 2006 ;Conclusion --- NPC recurrence was highly related to EBV DNA level, but not always coincided With an asymptomatic rise in the plasma EBV DNA level, tumor recurrence should be considered;EBV DNA level and distant metastasis ;EBV