口蹄疫新型疫苗研究进展教案.PDF

微生物学通报 NOV 20, 2009, 36(11): 1750~1757 Microbiology © 2009 by Institute of Microbiology, CAS tongbao@ 专论与综述 口蹄疫新型疫苗研究进展 曹轶梅 1,2 卢曾军 1,2 田飞鹏1,2 刘在新 1,2* (1. 730046) (2. 730046) 摘 要: 口蹄疫(FMD)是一种严重威胁畜牧业发展的重要传染病, 目前世界上许多国家和地区都 有该病的流行与发生。其控制措施主要是疫苗免疫, 虽然传统疫苗在该病的防控中起了重要的作 用, 但也存在着诸多的缺点。因此研制新型的 FMD 疫苗是今后的发展方向。本文结合实验室在 FMD 新型疫苗研究方面所开展的探索性研究工作, 综述了国内外在FMD 基因工程弱毒苗或灭活 苗、蛋白质和合成肽疫苗、空衣壳疫苗、细胞因子增强型疫苗等研究领域所取得的进展。 关键词: 口蹄疫, 传统疫苗, 新型疫苗 Recent Advances of New-type Foot-and-mouth Disease Vaccines CAO Yi-Mei1,2 LU Zeng-Jun1,2 TIAN Fei-Peng1,2 LIU Zai-Xin1,2* (1. Lanzhou Veterinary Research Institute of Chinese Academy of Agricultural Sciences, State Key Laboratory of Veterinary Etio- logical biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou, Gansu 730046, China) (2. Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou, Gansu 730046, China) Abstract: Foot-and-mouth disease is a devastating disease of livestock that has had a significant impact on world economies and prevailed in many countries and areas throughout the world. Although the traditional inactivated vaccine is effective, there are a number of concerns with its use. So many researchers have at- tempted to develop new vaccines that may provide additional tools to help control FMD in future. In this paper, based on the research work in our lab, we reviewed the international research progress on the new-type vaccines of FMD including genetically engineered live-attenuated