智能高分子作业-supramolecular polymer.ppt

(A) Is Generalized schematic of host (red) interaction with its corresponding guest (blue) to form a guest?host complex (purple). (B) is the Schematic representation of 4 host species, represented by pillar[5] arene, calix[4] arene, cyclodextrin, and cucurbit[n]uril. * This is the Schematic representation of guest?host polymeric assemblies.These are 5 different Molecular :(A, B) CD?PEO pseudopolyrotaxanes; (C) supramolecular polymers from heterobifunctional (D) separate, pendant modification by βCD and adamantane; and(E) separate, pendant modification of polymers by methyl viologen  * Figure 3. Guest?host hydrogel injection. (A) Hydrogels are preformed within the syringe through guest?host bonds (i), which are broken by shearstress (τ) within the needle (ii). Following extrusion, bonds rapidly reform (iii) to enable retention within the tissue. Subsequent disassembly of thehydrogel in vivo occurs through spontaneous dissociation of the dynamic bonds and resultant surface erosion of the polymer (iv). (B) Representativeoscillatory time sweep demonstrating initial hydrogel mechanics (i), yielding to enable flow under high strain (ii), and rapid recovery (iii) such asduring hydrogel injection. Adapted from ref 65. Copyright 2013 American Chemical Society. * and to impart molecular carrier functionality to nanoparticles (C). Furthermore, in hydrogel systems, guest?host chemistry may be used to tune cross-linksin hydrogels for the diffusive release of biomacromolecular therapeutics (D) or to promote retention of small molecule therapeutics within thehydrogel (E). * Figure 5. Schematic representation of in situ supramolecular hydrogel formation including cell encapsulation (A), through mixing of cucurbit[6]urilconjugated hyaluronic acid (CB[6]?HA) and polyamine-conjugated HA (PA?HA) and subsequent modular modification with various CB[6]-bound tags. The chemical structures (B) of CB[6] and PAs of diaminohexane (DAH) and spermine (SPM). Adapted with permission fr