真菌代谢产物的药物发现.PDF

Mycosystema 菌 物 学 报 15 March 2011, 30(2): 151-157 jwxt@ ISSN1672-6472 CN11-5180Q ©2011 Institute of Microbiology, CAS, all rights reserved. 真菌代谢产物的药物发现 ——资源、问题和策略 * 郑维发 徐州师范大学江苏省药用植物生物技术重点实验室 徐州 221116 摘 要：本期菌物学报“真菌生物活性代谢产物的药物发现专刊”刊登了 7 篇深度论述的综述性文章，19 篇研究论文及 2 篇简报。内容涉及植物内生真菌产紫杉醇/紫杉烷的研究现状及最新进展、虫草菌素产生菌的培养策略及其药理学研究进展、 灵芝三萜和胞外多糖生物合成的调控策略、淡水和海水真菌活性代谢产物研究进展等。本期内容还涉及内生真菌的分离和鉴 定、海洋真菌的代谢产物分离、大型真菌的培养、代谢产物的分离及其药理学研究、酚类化合物测定方法、蛋白质组学以及 生物转化等研究，基本体现了我国真菌代谢产物新药发现研究的最新进展，对真菌代谢产物合成调控、活性代谢产物分离和 结构鉴定以及药理学研究等都具有重要的参考价值。 关键词：真菌代谢产物，新药发现，资源，问题 对策 Drug discovery from fungal metabolites: a review of the papers in this monographical issue of Mycosystema concerned with the natural resources, problems and strategies * ZHENG Wei-Fa Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, Xuzhou Normal University, Xuzhou 221116, China Abstract: This monographical issue of Mycosystema contains 7 in-depth reviews, 19 research articles and 2 short communications on the latest and most important progress in the resources, problems and strategies for drug discovery from fungal metabolites. It covers the current progress and latest achievements on production of taxol by entophytic fungi, strategies and latest developments on culturing cordycepin-producing fungi, regulation strategies on biosynthesis of triterpenoids and extracellular polysaccharides produced by Ganoderma lucidum, current progress on bioactive metabolites from the fungi grown in fresh and sea water. This issue of Mycosystema also involves the isolation and identification of entophytic fungi, isolation of metabolites from sea-grown fungi, the 基金项目：国家自然科学基金（No.） * Corresponding author. E-mail: yyzw@ 152 Mycosystema culture for macro-fungi and