国产可降解涂层西罗莫司洗脱支架临床应用的可行性和价格优势.doc

国产可降解涂层西罗莫司洗脱支架临床应用的可行性和价格优势 安雅芳(天津市职业病防治院(工人医院)心内科，天津市 300020) 引用本文：安雅芳. 国产可降解涂层西罗莫司洗脱支架临床应用的可行性和价格优势[J].中国组织工程研究，2017，21():946-951. DOI:10.3969/j.issn.2095-4344.2017.06.022 ORCID: 0000-0002-3793-737X(安雅芳) 文章快速阅读： 文题释义： 药物洗脱支架：也可称之为药物释放支架，通过包被于金属支架表面的聚合物携带药物，当支架置入血管内病变部位后，药物自聚合物涂层中通过洗脱方式有控制地释放至心血管壁组织而发挥生物学效应。文中的药物洗脱支架列举了2种，即Tivoli支架和Endeavor支架。其中Tivoli支架为新型的西罗莫司药物洗脱支架，骨架为钴铬合金，支架壁厚度为0.003 1英寸，采用开环设计，金属覆盖率为14.06%，生物可降解涂层包含西罗莫司，聚合物为聚乳酸羟乙酸共聚物，载药量为2.2 μg/mm2，药物涂层可在6个月内完全降解吸收。Endeavor支架涂层为zotarolimusABT-578)药物，支架还涂有磷酸胆碱聚合物有较高的生物相容性，其载药量为10 μg/mm2。 omemade sirolimus-eluting stent with biodegradable coating: feasibility and price advantage An Ya-fang (Department of Cardiology, Tianjin Occupational Diseases Prevention and Therapeutic Hospital (Tianjin Workers’ Hospital), Tianjin 300020, China) Abstract BACKGROUND: The homemade sirolimus-eluting stent with biodegradable coating (Tivoli stent) is cheaper than the imported zotarolimus-eluting stent (Endeavor stent) by half. Tivoli stent has been widely applied in clinic gradually, and its safety and efficacy will be recognized. OBJECTIVE: To explore the feasibility and price advantage of the Tivoli stent versus Endeavor stent. METHODS: 110 patients with coronary heart disease in Tianjin Occupational Diseases Prevention and Therapeutic Hospital (Tianjin Workers’ Hospital) from January 2006 to January 2016 were selected and randomly allotted to two groups, followed by treated with Tivoli or Endeavor stents, respectively. The procedural success rate, the serum level of C-reactive protein before and 1 week after treatment, coronary angiographic results at 8 months after treatment, as well as the incidence of major adverse cardiac and stent thrombosis events during the 270-day follow-up were observed. RESULTS AND CONCLUSION: The successful rate of stent implantation was 100% in both groups. The serum level of C-reactive protein in the patients subjected to Tivoli stent before and 1 week after operation showed no signi