p-p65 BS4135 南京医科大学(英文版).pdfVIP

Hindawi Publishing Corporation Mediators of Inflammation Volume 2011, Article ID 670613, 10 pages doi:10.1155/2011/670613 Research Article Nuclear Factor-Kappa B Activity Regulates Brain Expression of P-Glycoprotein in the Kainic Acid-Induced Seizure Rats Nian Yu,1 Qing Di,1 Hao Liu,2 Yong Hu,1 Ying Jiang,1 Yu-kui Yan,3 Yan-fang Zhang,1 and Ying-dong Zhang1 1 Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, 264 Guangzhou Road, Nanjing, Jiangsu 210009, China 2 Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA 3 Department of Neurology, Huzhou Central Hospital, Huzhou, Zhejiang 313000, China Correspondence should be addressed to Qing Di, diqing@ Received 5 October 2010; Revised 24 December 2010; Accepted 8 January 2011 Academic Editor: Muzamil Ahmad Copyright © 2011 Nian Yu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This study was aimed to investigate the effect of NF-κB activity on the seizure susceptibility, brain damage, and P-gp expression in kainic acid- (KA-) induced seizure rats. Male SD rats were divided into saline control group (NS group), KA induced epilepsy group (EP group), and epilepsy group intervened with NF-κB inhibitor-pyrrolidine dithiocarbamate salt (PDTC group) or with dexamethasone (DEX group). No seizures were observed in the rats of NS group. Compared with NS group, increased P-gp expression and NF-κB activation in the rat brain of the EP group were observed after KA micro-injection. Both PDTC and DEX pre-treatment significantly increased the latency to g