AHS 淋巴瘤干细胞移植.ppt

* The Mantle Cell Lymphoma International Prognostic Index (MIPI) is superior to the International Prognostic Index (IPI) in predicting survival following intensive first-line immunochemotherapy and autologous stem cell transplantation (ASCT) * * * * * * 展望：如何提高ASCT疗效 移植前尽量降低肿瘤负荷，PET/CT Tandem 移植，双移植（auto-auto; auto-allo ） 新药治疗 ， thalidomide？ PD-1单抗 长效干扰素 其他 中山大学肿瘤医院 SUN YAT-SEN UNIVERSITY CANCER CENTER 移植病房启用20年纪念 中山大学肿瘤医院 SUN YAT-SEN UNIVERSITY CANCER CENTER THANK YOU！ 中山大学肿瘤防治中心 * * * * * * * * * * * * Intensive Chemotherapy Followed by Hematopoietic Stem-Cell Rescue for Refractory and Recurrent Primary CNS and Intraocular Lymphoma: Société Fran?aise de Greffe de Mo?lle Osseuse-Thérapie Cellulaire Carole Soussain, /content/26/15/2512.long * HIGH-DOSE CHEMOTHERAPY WITH AUTOLOGOUS STEM CELL TRANSPLANTATION FOR ELDERLY PATIENTS WITH RELAPSED/ REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA: A RETROSPECTIVE ANALYSIS FROM THE ADULT LYMPHOMA WORKING GROUP OF THE JAPAN SOCIETY FOR HEMATOPOIETIC CELL TRANSPLANTATION * * * * * EFS, event-free survival; FL, follicular lymphoma; PFS, progression-free survival. ? Another option would be to consolidate patients with upfront hematopoietic stem cell transplantation. At least 4 prospective, randomized trials including studies from the French, German, and Italian Cooperative Groups have examined this approach. As shown on this slide, all of the trials showed improvements in progression-free survival or event-free survival with hematopoietic stem cell transplantation relative to controls. For example, the Italian trial showed an improvement in the 4-year event-free survival from 28% for controls to 61% with upfront transplantation as consolidation therapy. Evolving Standards of Care in Non-Hodgkins Lymphoma * * * * * * * * * 研究流程 复发FL: 移植前利妥昔单抗净化和/或移植后维持EBMT一项前瞻性研究, ASCT Ruth P. J Clin Oncol 31:1624-1630 10 yr PFS: 48.6% vs. 42%(P=0.18) Effect on PFS 10 yr PFS: 54% vs. 37%(P=0.12) 是否Rituxim