腹腔G尧G菌感染致MODS的腹水尧血清中炎性因.PDFVIP

窑1626窑 南方医科大学学报(JSouthMedUniv) 2010;30(7) + - 腹腔G 尧G 菌感染致MODS 的腹水尧血清中炎性因子的差异 瞿 嵘袁杨思敏袁戴伟群袁叶初阳袁纪妍渊惠州市中心人民医院ICU袁广东惠州516001冤 + - 摘要院目的 探讨腹腔G 尧G 菌感染致MODS 患者腹水及血清中炎性因子的差异遥 方法采用酶联免疫吸附法分别检测 在我院综合 + - ICU 救治的27 例腹腔G 尧G 菌感染致MODS 患者第 1天血清尧腹水中IL-6尧IL-8尧IL-10尧TNF-琢和LPS 浓 度遥 结果 - + G 组血清腹水中LPS尧TNF-琢水平明显高于G 组(P0.05)袁但两组IL-6尧IL-8尧IL-10浓度水平差异无统计学意 + 义(P0.05)遥 结论可以通过早期检测腹腔G 尧G 菌感染致MODS 血清尧腹水中LPS尧TNF-琢水平袁早期诊断腹腔感染- 致MODS 患者病原菌的类型袁指导临床用药遥 + - 关键 院多器官功能障碍综合征曰G 菌曰G 菌曰炎性因子 中图分类号院R63 文献标识码院A 文章编号院1673-4254渊2010冤07-1626-02 DifferencesinserumandascitescytokineproductioncausedbyGram-positiveor -negative bacterialinfectioninpatientswithmultipleorgandysfunctionsyndrome QURong,YANGSi-min,DAIWei-qun,YEChu-yang,JIYan ICUofHuizhouMunicipalCentralHospital,Huizhou516001,China Abstract: Objective ToobservethedifferencesinthecytokinelevelsintheserumandascitescausedbyGram-positiveor Gram-negativebacterialinfectioninpatientswithmultipleorgandysfunctionsyndrome(MODS). MethodsThecytokinesin theserumandascitesofthepatientswereexaminedbyenzyme-linkedimmunosorbentassayin27patientswithMODSdueto Gram-positive(n=13)orGram-negative(n=14)bacterialinfectionatday1. ResultsThelevelsofLPSandTNF-awerehigher inthepatientswithGram-negativebacterialinfectionthaninpatientswithGram-positiveinfection(P0.05),butthelevelsof IL-6, IL-8andIL-10remainedcomparablebetweenthetwogroups (P0.05). ConclusionTestingofLPSandTNF-ainthe serumandascitesofpatientswithMODScausedbyGram-positiveor-negativebacterialinfectionmayhelptoidentifythe pathogensforperitonitisresultinginMODS. Keywords:multipleorgandysfunctionsyndrome;Grampositivebacteria;Gramnegativebacteria;cytokine 腹腔感染是较为严重的并发症袁特别