生物高分子材料血液相容性研究.pdfVIP

生物高分子材料血液相容性研究/王 杨等 • 77 • 生物高分子材料血液相容性研究铃 五扬，都红，王震莲，管晓玉，赵涛，五凯 (西北大学化工学院.西安 710069) 摘要 生物高分子材料广泛应用于临床民疗，可用作人工血管、起搏器、组织工程支架等，因而必须具备良好 的血浪相容性。综述了生物高分子材料血液相容性的研究现状，立委包括被血、血栓形成机理以及抗凝血系统等.重 点介绍了高分子材料梳入体内引起凝..úa..J.t血栓形成的具体机制，阐述了设计微相分离给构、化合物接枝改性、引入生 物活性分子、材料表面内皮化等改善材料血液相容性的主要途径。最后从分子生物学角度出发展望了今后高分子材 料改性的研究方向。 关键诩 生物商分子材料血液梢容性凝血机理改性 Study 00 Blood Compatibility of Biopolymer Material WANG Yang , HAO Hong , WANG Junlian , GUANG Xiaoyu , ZHAO Tao , WANG Kai (Sch∞1 of Chemical Engineeri吨. Northwest University , Xian 710069) Abs仕act Biopolymer materials are widely used in clinical treatment , which can be used as artificial blood ves- 时， pacemaker. scaffolds for tissue engineering , etc. Thus good haemocompatibility is r叫uired. The research status of haemocompatibility of biopolymer materials is reviewed , such as the mechanisms of clotting and thrombosis. antÎ唰 coagulant system; then the mechanisms of clott叫and thrombosis induced by leading in biopolymer materials are irγ troduc时. and the major pathways of modification used to enhance the haemocompatibility of biopolymer materials are described , mainly including designing microphase separated structures , compounds grafting , bioactive molecules bin- ding. surface endothelialization , etc. At last the direction of research based on the perspective of molecular biology in the future is forecasted. Keyw刷由 biopolymer materials , haemocompatibility , c10tting mechanism. modificatìon 因子(丁F)租娥的外惊性途径产生少最凝血酶$放大阶段是利 生物高分子材料是与生物系统结合，以诊断、治疗或替 用启