生物黏附药物传递系统的评价方法与应用.pdfVIP

• 631 中国医药工业杂志 Chinese Journal of Pharmaceuticals 2015 , 46 (6) _1Þ~ . Z 综述与专论 3 ?咱rc.ι‘民‘U电c.c.C.C:‘二‘ 生物黠附药物传递系统的评价方法与应用 孙有丽，马晋隆*，倪睿，史家骏，黄乐乐 (中国医药工业研究总院药物制剂国家工程研究中心，创新药物与制剂工艺国家重点实验室，上海 201203) 摘要:生物妻自附给药系统通过悉附到教膜教液或上皮细胞表面，延长药物在给药部位或吸收部位的滞留时间，从而提高 治疗局部或全身疾病的效果，成为现代药物新剂型研究的热点。本文系统综述了生物菊附给药系统的体内外评价方法， 包括测定劲附性能的体外方法及考察体内组织中分布和运转的技术，并总结了近年来生物教附性给药系统在胃肠道、口 腔、眼、鼻、阴道霜膜和皮肤方面应用的研究和进展，以期为产品的开发提供借鉴。 关键词:生物薪附给药系统;评价方法:茹附性能:应用:综述 中图分类号: R944.9 文章编号: 1001-8255 (2015) 06-0631-08 文献标志码:A DOI: 10.16522/ki.啪h.2015.06.021 Evaluation Methods and Applications of Bioadhesive Drug Delivery System SUN Youli , MA Jinlong气 NI Rui , SHI Jiajun , HUANG Le1e (State Key Lab. ofNew Drug and Pharmaceutical Process. National Pharmaceutical Engineering Research Center, China State lnstitute ofPharmaceutical lndus町; Shanghai 201203) ABSTRACT: Bioadhesive drug delivery system (BDDS) has become a hot research point for its adhesion to a mucosa , mucus or the surface of epithelial cells , which prolongs the residence time to improve the local or systemic therapeutic effect. This paper summarizes the evaluation methods of BDDS , inc1uding measuring the bioadhesive ability in vitro and investigating the distribution and transportation in vivo. The recent advances of the applications of BDDS to gastrointestinal tract , oral cavity, ophthalmic , nasal , vaginal mucosa and transdermal administrations have also been reviewed to provide reference to related researches. Key Words: bioadhesive drug delivery system; evaluation method; bioadhesive ability; application; review 生物妻自附主要指天然或合成聚合物与黠膜或上 义。当与黠膜发生茹附时，蒙古附作用最初是发生在 皮细胞间