磁共振引导高强度聚焦超声治疗子宫肌瘤临床研究_陈军臣.pdfVIP

·1512 · 中华临床医师杂志(电子版)2014 年 4 月第 8 卷第 8 期 Chin J Clinicians(Electronic Edition),April 15,2014,Vol.8,No.8 ·综述· 磁共振引导高强度聚焦超声治疗子宫肌瘤临床研究 磁共振引导高强度聚焦超声（MRgHIFU ）利用 MRI 准确解剖定位引导及实时温度 监测功能和高强度聚焦超声波，从体外将超声能量聚集于治疗靶区使其温度瞬间升高，选择性灭活 体内某特定区域病灶，而对病灶周围及声通道上的组织结构无损害或损害很少。本文对 MRgHIFU 治疗子宫肌瘤的作用机制、温度监控技术、临床治疗适应证和禁忌证、治疗疗效和并发症及其优势 和不足进行综述。 磁共振成像； 平滑肌瘤； 聚焦超声 Clinical research of treatment of uterine fibroids by MR-guided high intensity focused * * ultrasound Chen Junchen , Xu Yonghua, Wang Zhibiao, Chen Wenzhi. School of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, China Corresponding author: Xu Yonghua, Email: yhxu@ 【Abstract 】 Magnetic resonance guided high intensity focused ultrasound (MRgHIFU) employs MRI’s function such as accurate anatomical guidance and real-time temperature mapping for monitoring HIFU to accumulate ultrasound energy at the focal region, which would result in the temperature elevate in the targeted tissues for ablation without injures of the structures around the focus and at acoustic path. In this paper, the mechanism of MRgHIFU treatment of uterine fibroids, temperature mapping technology, clinical indications and contraindications, therapeutic efficacy and complications, and the advantages and disadvantages were reviewed. 【Key words 】 Magnetic resonance imaging; Leiomyoma; Focused ultrasound  [5] 近十多年以来聚焦超声作为一种非侵入性的 温热疗方法 。20 世纪 50 年代美国 Frey 兄弟研制 热消融治疗方法，已成功应用于肿瘤临床治疗并取 了世界上第一台聚焦超声治疗设备，并在印第安纳 得了良好的疗效，其临床关注度不断上升[1-2]。MRI 大学用于帕金森病的神经外科手术治疗并取得成 引导高强度聚焦超声[MR-guided high intensity 功[6-7] 。后来由于药物对帕金森病治疗的成功以及 focuse