神经激肽B及其受体在子痫前期患者胎盘、脐血管的表达.pdfVIP

2007年12月第l6卷第12期 Prog Obstet G~neeol。Dec．20o7。V01．16．No．12 · 论著 · 神经激肽B及其受体在子痫前期患者 胎盘、脐血管的表达 刘燕燕，陈汉平 (华中科技大学同济医学院附属同济医院妇产科，武汉 430030) 【摘要】 目的：探讨子痫前期患者胎盘、脐血管中神经激肽B(NKB)及其受体的表 达。方法：用免疫组化sP法检测40例子痫前期患者胎盘与脐带组织中NKB及其受体的 分布与定位，以20例正常产妇作为对照。通过高清晰度彩色病理图文分析系统进行定量 分析。结果：轻、重度子痫前期胎盘组织中，其NKB含量明显高于对照组(P0．05，P 0．01)，神经激肽受体(NKR)含量亦高于对照组(P0．05，P0．05)。重度子痫前期组 脐静脉NKR含量高于对照组(P0．05)。结论：NKB及其受体可能参与子痫前期发病机 制。 【关键词】 子痫前期；胎盘；脐带；神经激肽B；神经激肽B受体 中图分类号：R714．24 6 文献标识码：A 文章编号：1004—7379(2007)12—0914—03 Levels of neurokinin B，neurokinin B receptor in placental and umbilical cord in pre- eclampsia．Liu Yanyan，Chen Hanping．Department of Obstetrics and Gynecology，rongii Hospi— tal，Tongii Medical College ofHuazhong University ofScience and Technology，Wuhan 430030 【Abstract】 0bjective：To study the expression of neurokinin B(NKB)，neurokinin B receptor(NKR)in placental tissue and umbilical cord of preeclampsia．Methods：Immunohis— tochemistry was used to observe the expression and distribution of NKB，NKR in placenta tis— sues and umbilical cords．High resolution pathological image analysis system(HPIAS)was used to determine the quality of NKB and NKR．Results：The levels of NKB expression of pla— centa on lightly and severe preeclampsia patients were significant higher than that of normal group(P0．05，P0．O1)，the levels of NKR expression of placenta on lightly and severe preeclampsia patients were higher than that of normal group(P0．05，P0．05)． rhe expres— sion of NKR of umbilical vein on severe was higher than that of normal group(P0．05)． Conclusion：The levels of NKB and NKR expression in preeclampsia increase obviously and they may be involved in the pathogenesis of preeclampsia． 【Key words】 Preeclampsia；Placenta；Umbilical cord；Neurokinin B；Neurokinin B receptor 子痫前期(preeclampsia)的发生可能与导致”胎 热点，国内尚未见相关实验报道。本研究旨在检测 盘浅着床”，胎盘灌注减少，滋养