胆囊癌和胆管癌化疗药物敏感性测定.pdfVIP

中国临床医学 2OO7年 1 2月 第 14卷 第6期 Clinical Medical Journal of China，2007．Vo1．I4，No．6 805 · 论著· 胆囊癌和胆管癌化疗药物敏感性测定 虞腊青 周 华 刘厚宝 金赘杰 沈振斌 童赛雄 王炳生 摘要 目的：探讨胆囊癌和胆管癌对化疗药物的敏感性。方法：采用四氮唑比色法检测 13例胆囊癌和32例胆管癌对13肿化 疗药物的敏感性。结果：胆囊癌和胆管癌的药物敏感性由高到低依次为秦素(TAI川()() ．健择(GZ)75 、米托蒽醌(Mito) 66．7 ，长春新碱(VCR)58．3 、羟基喜树碱(HPT)58．3 、丝裂霉素(MMC)48．9 、卡铂(CP)48．5 、、顺铂(DDP)46．7％、 表阿霉素(EADM)46．7 、阿霉素(ADM)30．3 、j一氟尿嘧啶(5-FU)33．3 、甲胺喋呤(MTX)1 5．6 。结论：胆囊癌和胆管 癌对TAI ( z、Mito、VCR、HI T较敏感，MMC、CI 、DDP、EAI)M次之；体外药敏试验有助于临床个体化的化疗用药。 关键词 胆囊癌； 胆管癌； 体外药敏试验 中图分类号 R735．8 文献标识码 A Drug Susceptibility Test in Carcinoma of Gallbladder and Cholangiocarcinoma y【_，Laqing ZH()U Hua LJU Houbao J J Yunjie! SHE Zhenbin TONG Skai，riong! W G Bingsheng 1．Department of General Surgcry．the People s Hospital of Jurong C~unty in Jiangsu Provbice，Jiangsu Jurong 21 2400；2． Departnleltt of General Sureer3·，Zhongshan Hospital，Fudan University，Shaltghai 200032 Abstract 0l】-iective：To investigate the sensibility of chemotherapy in carcinoma of gallbladder and cholangiocarcinoma．Meth_ ogs：The sensibility of 1 3 chemotherapeutics were measured in 1 3 cases of carcinoma of gallbladder and 32 cases of cholangiocar— cinoma by MTT assay．Results：The sensiti＼ ity of the main theraputic drugs were as follows：TAI 1 00 ．GZ75 ．Mito66． 7 ．VCR 58．3 ．HPT 58．3 。MMC 48．9 。CP 48．5 F0，DDP 46．7 ，EADM 46．7 ，ADM 30．3 ，5-Fu33．3 ， MTX1 5．6 ．Conclusion：Carcinoma of gallbladder and cholangioearcinoma are not sensitive to chemotherapy；TAI GZ、Mito、 VCR、HPT are sensitive for cholangiocarcinoma and carcinoma of gallbladder，MMC．CP．DDP，and EADM as second．The susceptibility test in vitro is helpful to the individualized chemotherapy． Key Words Cholangiocarcinoma； Carcinoma of gallbladder； Susceptibility test in vitro 胆道恶性肿瘤早期缺乏典型症状而不易诊断， PPC)，2()C保存备用。所有药物的临床血浆峰浓 同时因其特殊的解剖结构和复杂的毗邻关系，根治 度