银杏叶提取物对老年大鼠的抗衰老研究.pdfVIP

第24卷第4期(第13页) 湖北民族学院学报·医学版 Vo】．24 NO．4 P．13 2007在 Journal of Hubei Institute for Nationalities·Medical Edition 2OO7 银杏叶提取物对老年大鼠的抗衰老研究 覃红斌 湖北民族学院医学院(湖北恩施445000) 【摘要】目的 研究银杏叶提取物(GBE)对老年大鼠抗衰老的作用。方法 GBE连续胃饲老年大鼠30 d后取血 液、肝脏、脑组织，测定其超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH—Px)活力、丙二醛(MDA)含量及单胺 氧化酶(MAO)活力。结果 与老年对照组比较，老年实验组血液和肝脏中SOD、GSH—Px活力显著增高，MDA含 量显著降低，其中GBE低剂量组与老年对照组比较P0．05，高剂量组与老年对照组比较P0．ol，MAO活力未见 显著差异；老年实验组脑组织中MDA含量和MAO活力显著降低，其中GBE低剂量组与老年对照组比较P0．05， GBE高剂量组与老年对照组比较P0．ol。结论 GBE可显著增高老年大鼠血液、肝脏和脑组织中SOD、GSH—Px 活力，使血液、肝脏和脑组织中MDA含量显著降低，具有一定的抗衰老作用。 【关键词】银杏叶提取物；抗衰老；SOD老年大鼠；GSH—Px；MDA 【中图分类号】R285．5 【文献标识码】A 【文章编号】1008—8164(2007)04—0013—02 Anti——Senile Effect of Ginkgo Biloba Extract on Senile Rats QING Hong——bin (Medical College，Hubei Institutefor Nationalities，Enshi 445000，China) 【Abstract】Objective To investigate the anti—senile effect of Ginkgo Biloba Extract on senile rats．Methods The blood．Iiver．brain tissue was collected after the rats were fed by Ginkgo Bi— Ioba Extract for 30 days．The content of MDA and activity of SOD．GSH—Px and MDA were measured．Results Compared with the senile controI group．the activity of SOD．GSH—Px n blood and Iiver in experimentaI group was significantly increased while the content of MDA was significantly decreased．Compared with the senile control group，the P value in low dose group and high dose group was P0．05．P0．O1 respectively．Conclusion the Ginkgo Biloba Extract has a certain ant —senile effects by increasing the activity of SOD．GSH—Px and decreasing the MDA in blood and Iiver of rats． 【Key words】Ginkgo Biloba extract；Anti—senile effect；SOD；Senile rats；GSH—Px；MDA 银杏叶中提取有药用成分的化合物主要为总黄 (12月龄)，青年大鼠(3月龄)，由武汉大学医学部 酮类及银杏内脂等，简称为银杏叶提取