频闪光对发育期豚鼠近视的影响.pdfVIP

· 388· 环境与健康杂志2007年6月第24卷第6期 J Environ Health，June 2007，Vo1．24，No．6 【论著】 文章编号：1001—5914(2007)06—0388 03 频闪光对发育期豚鼠近视的影响 王红，庄康，陶远，王珍红，李镜海 摘要：目的 探讨光污染对发育期豚鼠近视形成的影响。方法 选择健康3周龄豚鼠60只，随机分为6组(红光组、 黄光组、绿光组、白光组、自然光1组、自然光2组)，每组10只，分别用红、黄、绿、白色闪烁光照射，闪烁方式为亮2 s，暗 2 s，交替进行，4个有色光组光照度均为800 lux，均放在完全密闭的纸箱中饲养。自然光 1组用正常自然光照射，放在四 周密闭而上方开放的纸箱中饲养；自然光2组用正常自然光照射，放在视野开阔的笼中饲养。分别在暴露前、暴露后6周 用散瞳检影验光法测量屈光度，用A超测量眼轴长度。结果 与自然光1组(0．75D)相比，暴露后6周红、黄、绿、白光组 屈光度分别为一8．75 D、一6．56 D、一3．88 D、-4．84 D的，且差异有统计学意义( I0．01)，眼轴延长。结论 闪烁光能促进豚鼠 眼轴延长、诱发近视，且不同波长的单色闪烁光对近视形成的影响不同。 关键词：光；近视；闪烁光 中图分类号：R994．6 文献标识码：A Effects ofLight Pollution on Development ofMyopia in Guinea Pigs WANG Hong, ZHUANG Kang, TA0 Yuan~ et ． DepartmentofOphthalmology,Qilu Hospital,Shandong University,Ji’nan,Shandong 250011，China Abstract：Objective To study the effects of flashing light exposure on development of myopia in guinea pigs．Methods Sixty pigmented guinea pigs aged 3 weeks were randomly divided into six groups．Animals in group I，Ⅱ，ⅢandⅣwere exposed to the flashing light(including red，yellow，green and white respectively)for 6 weeks．The illumination cycle was 12 hours light／12 hours dark．Th e flashing intensity was 800 lux，every flash includes 2 seconds light and 2 seconds dark．The above four groups were reared in the closed tighdy paper box．Animals in group V were reared in the closed tightly paper box with natural light，but group Ⅵ in a sight-widen cage and irradiated by natural light．After 6 weeks of treatment，the effects of flashing light on eye myopia and axial development were assessed by cycloplegic retinoscopy，A-scan uhrasonography．Results At the end of the treatment，guinea pigs reared in f