IGFBP4在大肠癌细胞中对Wntβ-catenin信号通路调控作用的研究.pdfVIP

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IGFBP4在大肠癌细胞中对Wntβ-catenin信号通路调控作用的研究.pdf

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IGFBP4在大肠癌细胞中对Wntβ-catenin信号通路调控作用的研究

目录中文摘要·········································································································1 英文摘要·········································································································4 研究论文 IGFBP4 在大肠癌细胞中对Wnt/ β-catenin 信号通路调控作用的研究前言·········································································································8 材料与方法···························································································10 结果·······································································································2 1 附图·······································································································23 附表·······································································································28 讨论·······································································································31 结论·······································································································34 参考文献·······························································································35 综述 Wnt/ β-catenin 信号通路与肿瘤的研究进展···································37 致谢···············································································································48 个人简历·······································································································50 万方数据中文摘要 IGFBP4 在大肠癌细胞中对Wnt/β-catenin 信号通路调控作用的研究摘要在世界范围内，大肠癌是危害人类健康的常见的恶性肿瘤之一，其发病率和死亡率均占第二位，并呈现逐年上升趋势。近年来，细胞内信号传导通路异常与肿瘤发生发展的关系成为医学界研究的热点问题。 IGFBP4(Insulin Like Growth Fa