2R，4R—APDC对癫痫大鼠学习和记忆影响的研究.pdfVIP

第45卷第l2期 山 东 大 学 学 报 (医 学 版) Vo1．45 No．12 2O07年 l2月 JOURNAL OF SHANDONG UNIVERSITY(HEALTH SCIENCES) Dec．2唧 文章编号：1671—7554(2007)12—1201—04 2R，4R—APDC对癫痫大鼠学习和记忆影响的研究 姚红。，冯亚波 ，赵秀鹤。，迟令懿 ，迟兆富。 (1．山东大学齐鲁医院神经内科，济南250012；2．山东省立医院神经内科，济南250021； 3．山东大学齐鲁医院神经外科，济南250012) 摘要：目的 研究Ⅱ组mGluRs激动剂2R，4R．APDC对癫痫后学习、记忆功能的影响。方法 复制氯化 锂一匹罗卡品大鼠模型，分别脑室内注射2R，4R．APDC和生理盐水，24 h后开始进行抬高迷宫实验(elevated plus Illaze test)和Morris水迷宫实验(morris water maze test)行为学检测。结果 致痫大鼠在注射2R，4R-APDC 后在开放臂的逃避时间显著缩短，进入开放臂的次数减少(P0．05)，逃避潜伏期明显缩短(P0．01)，空间 记忆能力和搜寻策略明显改善(P0．05)。结论 脑室内注射2R，4R．APDC可以明显改善癫痫大鼠的学习 和记忆能力。 关键词：2R，4R．APDC；癫痫；学习记忆 中图分类号：R742．1 文献标志码：A Effects of 2R，4R—APDC on learning and memory of rats after epilepsy YAO Hong~，FENG Ya．b02，ZHAO Xiu-he ，CHI Ling-yi ，CHI Zhao—fu (1．Department of Neurology，Qilu Hospital of Shandong University，Jinan 250012，China； 2．Department of Neurology，Shandong Provincial Hospital，Jinan 25002 1，China； 3．Department of Neurosurgery。Qilu Hospital of Shandong University，Jinan 250012，China) AbsI耐 ：Objective To study the effects of 2R，4R-APDC，a selective group II metabotropic glutamate receptor (H mGluR)agonist，on learning and memo~of rats after epilepsy．Methods SD rats were used to produce a lithium and piloearpine epileptic model，then they were intra-cerebroventricularly(icv)given 2R，4R-APDC or normal saline．24 hours later．the rats behavior was,determined by the elevated plus nlaIze test and the Morris water maze test．Result After the epileptic rats had been intra-cerebroventricularly given 2R and 4R-APDC．the time spent in the open aJTns was shortened and the number of entries to the open anns was reduced(P0．05)。the mean escape latency was,shortened (P0．01)，and the ability of spatial memo~and the efficiency of their search strategy were improved(P