2型糖尿病患者六项性激素与骨密度的相关性研究.pdfVIP

212 Labeled Immunoassays＆Clin Med，Dec．2007，Vo1．14，No．4 2型糖尿病患者六项性激素与骨密度的相关性研究 杨希秀 ，赵 鑫 ，毛红宇 ，迟流萤 ，肖正大。，王淑芳。 (山东省济南市中心医院1．核医学科；2．内分泌科，山东 济南 250013) 摘要：探讨2型糖尿病男性患者六项性激素水平与骨密度(BMD)的关系。应用 RIA检测 49例男性 2型糖尿病 患者和46例男性非糖尿病患者血清促卵泡生成激素(FSH)、促黄体生成激素(LH)、垂体泌乳素(PRL)、雌二醇 (E。)、孕酮(P)和睾酮(T)的水平；用双能X线吸收法测定患者桡骨远端 BMD，并按其 BMD值分为骨质疏松 (oP)组、骨量减少(L)组和骨量正常(N)组。结果显示，2型糖尿病组中BMD明显低于非糖尿病组，有显著差异 (PO．05)；在糖尿病组OP患者FSH、LH、PRL水平升高，E2、T、P水平降低，与非糖尿病组OP者比较有显著 性差异(PO．05或 PO．O1)；与BMD相关因素进行直线回归分析显示：OP患者BMD与FSH、LH、PRL水平 呈显著负相关，与T、E。、P水平呈正相关。作者认为男性 2型糖尿病患者伴有骨量丢失与垂体一性腺轴功能失衡 有关，性腺激素缺乏更容易患骨质疏松。 关键词：2型糖尿病； 性激素； 骨密度； 骨质疏松 中图分类号：R587．1 文献标识码：A 文章编号：1006—1703(2007)04—0212-03 Relationship Between Serum Sex Hormone and Bone Mineral Density in Patients with Type 2 Diabetes YANG Xi—xiu，ZHA0 Xin，MA0 Hong—yu，et a1． (Department of Nuclear Medicine，Jinan Central Hospital，Jinan 2500 1 3，China) Abstract：To explore the relationship between serum sex hormone level and bone mineral density (BMD)in male patients with type 2 diabetes，the serum levels of sex hormone(FSH，I H， PRL，E2，P and T)were measured by RIA in 49 male patients with type 2 diabetes and 46 male subjects without diabetes．The BMD of all patients in distal radius were measur甜 by dual—ener— gY x-ray absorption method．The patients were divided into 3 groups according to the value of BMD：osteoporosis group (OP)，loss bone mass group (L)，normal bone mass group(N)． The results showed that the BMD in patients with type 2 diabetes were markedly lower than that in patients without diabetes(P0．05)．The serum levels of FSH，LH and PRL in OP group with type 2 diabetes were significantly higher than those in OP group without diabetes(P d0．05)．The serum E2，T and P levels in OP group with type 2 diabetes were marke