2型糖尿病患者糖化血清白蛋白及糖化血红蛋白与胰岛β细胞功能的 .docVIP

2型糖尿病患者糖化血清白蛋白及糖化血红蛋白与胰岛β细胞功能的相关性 唐峻岭★ 李青 包玉倩 潘洁敏 贾伟平 上海交通大学附属第六人民医院内分泌代谢科 上海市糖尿病临床医学中心 上海市糖尿病重点实验室 上海市糖尿病研究所 【摘要】 目的 探讨2型糖尿病患者糖化血清白蛋白（GA）及糖化血红蛋白（HbA1c）与胰岛β细胞分泌功能及胰岛素敏感性的关系。方法 研究对象来源于我科2011年2月-2012年10月住院的508例2型糖尿病患者，所有患者入院后采取的降糖方案是饮食控制及口服降糖药物。入院后测定GA、HbA1c、空腹及餐后2小时血糖、胰岛素（FINS）））±11.8）岁，GA 为(18.97±4.54)%，HbA1c 为（7.47±1.53）%, GA/ HbA1c值为（2.54±0.31）0.05）0.05）0.05） 【关键词】 2型糖尿病；糖化血清白蛋白；糖化血红蛋白；胰岛素分泌 The association of glycated albumin and hemoglobin A1c with pancreaticβcell function in type 2 diabetic patients TANG Junling,LI Qing, BAO Yu-qian, PAN Jie-ming, JIA Wei-ping. Department of Endocrinology and Metabolism, Shanghai Jiaotong University affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Key Laboratory of Diabetes Mellitus,Shanghai Diabetes Institute, Shanghai 200233, China Corresponding author: LI Qing；E-mail: liqing2000519@ 【Abstract】anuary 2011 to October 2012. All the subjects were treated with diet control and oral hypoglycemic agent management after admission. Glucose, insulin and C-peptide levels were measured at fasting and 2h postprandial status. GA and HbA1c were analyzed by liquid enzymatic method and high performance liquid chromatography method, respectively. Homeostasis model assessment (HOMA) was used to evaluate basal insulin resistance (HOMA-IR) and pancreatic β cell secretory function (HOMA-β).Results (1)The recruited hospitalized patients included 276 males and 232 females with average age of （60.4±11.8）years, GA level of (18.97±4.54)%, HbA1c level of （7.47±1.53）% and GA/ HbA1c value of （2.54±0.31）0.05）0.05）0.05). Multiple stepwise regression analysis demonstrated that HOMA-β was independent factor for GA/HbA1c.Conclusions GA level had close association with pancreatic βcell secretory function and no relationship with insulin sensitivity in type 2 diabetic patients. HbA1c was not correlated with pancreatic β cell secretory function and insulin sensitivity. Key words Type 2 diabetes mellitus；Glycated albumin；Hemo