硬膜外舒芬太尼超前镇痛作用.pdfVIP

2008年6月第5卷第17期 · 药物与临床 · 硬膜外舒芬太尼超前镇痛作用 王金凤：l：，辛秀英，丁 彬 (潍坊市人民医院，山东潍坊 261041) 【摘要】目的：观察舒芬太尼超前镇痛作用。方法：择期子宫全切手术患者40例，年龄20～60岁，ASA I或Ⅱ级，随机 分为两组，每组20例。I组在切皮前硬膜外注入舒芬太尼10 g，Ⅱ组为对照组，注人生理盐水2 ml。观察术中硬膜 外用药量，术后感觉疼痛时间，镇痛药用量及术后VAS评分。结果：两组患者在手术时间上无统计学差异。术中麻 醉药用量，与Ⅱ组比较，I组明显减少(P0．05)，术后疼痛开始时间，I组比Ⅱ组明显延长(P0．05)，PCEA术后用药 量Ⅱ组I组，两组VAS评分相似。结论：切皮前硬膜外注入小剂量舒芬太尼，能明显降低术后患者PCEA用药量， 具有明显超前镇痛作用。 【关键词1舒芬太尼；硬膜外麻醉；超前镇痛 [中图分类号】R614 [文献标识码】B [文章编号】1673-7210(2008)06(b)-078-02 Effects of preemptive analgesia of sufentanil in epidural using WANG~n-fe ，XINXiu-ying，DING Bin (Department of Anesthesiology，Weifang People s Hospital，Weifang 261041，China) 【Abstract]Objective：To observe preemptive analgesia of sufentanil in epidural using．Methods：Forty ASA I or lI patients aged 20～60 years undergoing total hysterectomy under epidural anesthesia were randomly divided into two groups：group 1 was given sufentanil 10 g epidurally be~re skin incision．Group I1 was given 0．9％saline 2 m1．The required dosages of anesthetics in operation，postoperative time of aching，the postoperative required analgesic dosage and VAS score of pa— tients controlled epidural analgesia were observed．Results：The required dosage of anesthetics in operation was markly lower in group I than that in groupⅡ．The postoperative time of aching was significantly longer in group I than that in group I1．The postoperative required analgesic dosage was obviously smaller in group I than that in group I1．The VAS scores of two groups were similar．Conclusion：Small dose of epidural sufentanil before skin incision can lower the required analgesic dosage after operation，preemptive analgesia is produced effectively． 【Key words]Sufentanil；Epidural anesthesia；Preemptive analgesia